HBOC-201和rFVIIa在猪失控失血性休克中的院前复苏比较

Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2012-02-01 Epub Date: 2011-08-02 DOI:10.3109/10731199.2011.585615

Ashraful Haque, Françoise Arnaud, Kohsuke Teranishi, Tomoaki Okada, Bobby Kim, Paula F Moon-Massat, Charles Auker, Richard McCarron, Daniel Freilich, Anke H Scultetus

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引用次数: 4

摘要

在之前的剂量递增研究中，我们小组发现，与单独使用HBOC相比，90μg/kg rFVIIa与HBOC-201联合使用可减少失血量并改善生理参数。在这次对猪肝损伤模型的随访研究中，我们发现虽然没有发现血液学不良反应，并且证实了之前研究中观察到的趋势，但无法达到统计学意义。额外的临床前研究表明，以确定多功能血液替代品的最佳成分，用于临床创伤。

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Pre-hospital resuscitation with HBOC-201 and rFVIIa compared to HBOC-201 alone in uncontrolled hemorrhagic shock in swine.

In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma.

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来源期刊

Artificial cells, blood substitutes, and immobilization biotechnology 工程技术-材料科学：生物材料

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6-12 weeks