Quais Mohammad Mujawar, Ravi Naganoor, Mir Dilshad Ali, Naushad Malagi, Achyut Narayan Thobbi
{"title":"二八面体蒙脱石治疗印度儿童急性水样腹泻的疗效:一项随机临床试验。","authors":"Quais Mohammad Mujawar, Ravi Naganoor, Mir Dilshad Ali, Naushad Malagi, Achyut Narayan Thobbi","doi":"10.1093/tropej/fmr030","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine the effects and safety of dioctahedral smectite (DS) on the duration of acute watery diarrhea in children.</p><p><strong>Methods: </strong>A Randomized, open labeled, clinical controlled trial in a tertiary care hospital outpatient department (OPD) and emergency department. Participants were one hundred and seventeen children without any chronic illness between 2 and 5 years presenting to OPD, having acute watery diarrhea for <48 h with mild to moderate dehydration, not on antibiotics and requiring oral rehydration therapy. Intervention done was DS with a dose of 1.5 g thrice daily.</p><p><strong>Results: </strong>Freshly dissolved DS in a dose of 1.5 g thrice daily for 5 days significantly shortened the duration of acute watery diarrhea in children aged 2-5 years. There were no adverse effects on the use of DS. DS was acceptable to the children, and its administration was not accompanied with any side effects.</p><p><strong>Conclusion: </strong>DS reduces the duration of diarrhea in Indian children and prevents a prolonged course, and therefore, may consistently reduce the costs in treatment of acute watery diarrhea.</p>","PeriodicalId":17521,"journal":{"name":"Journal of Tropical Pediatrics","volume":"58 1","pages":"63-7"},"PeriodicalIF":1.8000,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/tropej/fmr030","citationCount":"21","resultStr":"{\"title\":\"Efficacy of dioctahedral smectite in acute watery diarrhea in Indian children: a randomized clinical trial.\",\"authors\":\"Quais Mohammad Mujawar, Ravi Naganoor, Mir Dilshad Ali, Naushad Malagi, Achyut Narayan Thobbi\",\"doi\":\"10.1093/tropej/fmr030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine the effects and safety of dioctahedral smectite (DS) on the duration of acute watery diarrhea in children.</p><p><strong>Methods: </strong>A Randomized, open labeled, clinical controlled trial in a tertiary care hospital outpatient department (OPD) and emergency department. Participants were one hundred and seventeen children without any chronic illness between 2 and 5 years presenting to OPD, having acute watery diarrhea for <48 h with mild to moderate dehydration, not on antibiotics and requiring oral rehydration therapy. Intervention done was DS with a dose of 1.5 g thrice daily.</p><p><strong>Results: </strong>Freshly dissolved DS in a dose of 1.5 g thrice daily for 5 days significantly shortened the duration of acute watery diarrhea in children aged 2-5 years. There were no adverse effects on the use of DS. DS was acceptable to the children, and its administration was not accompanied with any side effects.</p><p><strong>Conclusion: </strong>DS reduces the duration of diarrhea in Indian children and prevents a prolonged course, and therefore, may consistently reduce the costs in treatment of acute watery diarrhea.</p>\",\"PeriodicalId\":17521,\"journal\":{\"name\":\"Journal of Tropical Pediatrics\",\"volume\":\"58 1\",\"pages\":\"63-7\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2012-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1093/tropej/fmr030\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Tropical Pediatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/tropej/fmr030\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2011/4/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Tropical Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/tropej/fmr030","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2011/4/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
Efficacy of dioctahedral smectite in acute watery diarrhea in Indian children: a randomized clinical trial.
Objective: To determine the effects and safety of dioctahedral smectite (DS) on the duration of acute watery diarrhea in children.
Methods: A Randomized, open labeled, clinical controlled trial in a tertiary care hospital outpatient department (OPD) and emergency department. Participants were one hundred and seventeen children without any chronic illness between 2 and 5 years presenting to OPD, having acute watery diarrhea for <48 h with mild to moderate dehydration, not on antibiotics and requiring oral rehydration therapy. Intervention done was DS with a dose of 1.5 g thrice daily.
Results: Freshly dissolved DS in a dose of 1.5 g thrice daily for 5 days significantly shortened the duration of acute watery diarrhea in children aged 2-5 years. There were no adverse effects on the use of DS. DS was acceptable to the children, and its administration was not accompanied with any side effects.
Conclusion: DS reduces the duration of diarrhea in Indian children and prevents a prolonged course, and therefore, may consistently reduce the costs in treatment of acute watery diarrhea.
期刊介绍：
The Journal of Tropical Pediatrics provides a link between theory and practice in the field. Papers report key results of clinical and community research, and considerations of programme development. More general descriptive pieces are included when they have application to work preceeding elsewhere. The journal also presents review articles, book reviews and, occasionally, short monographs and selections of important papers delivered at relevant conferences.
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