聚合猪血红蛋白(polyhb)在大鼠换血模型中的药效学研究。

Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-06-01 Epub Date: 2011-03-07 DOI:10.3109/10731199.2011.559584

Hongli Zhu, Xiaodong Dang, Kunping Yan, Penggao Dai, Chao Luo, Jun Ma, Yan Li, Thomas Ming Swi Chang, Chao Chen

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引用次数: 13

摘要

本研究的目的是评估在交换输血模型中聚合猪血红蛋白(polyhb)的药效学特性。两组大鼠均接受了相当于估计总血容量(70 ml/kg) 120-140%的polyhb或hetastarch交换输血。结果表明，polyhb保持了血流动力学稳定性，并表现出良好的体积扩张能力。此外，polyhb有效地逆转了大量体积交换引起的无氧代谢。与hetastarch相比，polyhb增加血氧含量和组织氧合。这些特性有助于提高polyhb组大鼠的生命维持效率。

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Pharmacodynamic study of polymerized porcine hemoglobin (pPolyHb) in a rat model of exchange transfusion.

The objective of the present study is to evaluate the pharmacodynamic properties of polymerized porcine hemoglobin (pPolyHb) in an exchange transfusion model. Each of two groups of rats received a volume of pPolyHb or hetastarch that equalled 120-140% of estimated total blood volume (70 ml/kg) exchange transfusion. The results showed pPolyHb retained hemodynamic stability and exhibited superior volume expansion capability. Furthermore, pPolyHb effectively reverse anaerobic metabolism caused by a large amount of volume exchange. In comparison with hetastarch, pPolyHb increased blood oxygen content and tissue oxygenation. All these properties contribute to a higher effectiveness in sustaining the lives of rats in pPolyHb group.

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来源期刊

Artificial cells, blood substitutes, and immobilization biotechnology 工程技术-材料科学：生物材料

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6-12 weeks