Jean Lacau St Guily, Christine Clavel, Claire Okaïs, Jean-Luc Prétet, Agnès Beby-Defaux, Gérard Agius, Philippe Birembaut, Anne-Carole Jacquard, Yann Léocmach, Benoît Soubeyrand, Didier Riethmuller, François Denis, Christiane Mougin
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引用次数: 32
摘要
背景:扁桃体癌的发病率在一些国家有所增加。法国关于扁桃体癌中HPV患病率的数据很少。因此，本研究的目的是评估扁桃体组织学样本中HPV的总体和类型特异性患病率。方法:这项法国回顾性多中心研究涉及全国12个中心。纳入2000年至2009年间收集的185例经证实诊断为扁桃体浸润性癌的组织学样本。根据性别、年龄和肿瘤的组织学类型研究HPV患病率。结果:扁桃体癌中HPV的总体患病率为57%。HPV阳性扁桃体病例(60±11.2)和HPV阴性扁桃体病例(59±9.6)的平均诊断年龄相当。女性的HPV患病率明显高于男性(28/35 vs 78/150, P = 0.003)。约53%的扁桃体病例感染了单一类型的HPV。只有8个(4%)样本感染了一种以上的HPV类型。在HPV阳性样本中，89%的扁桃体病例中发现了HPV 16。所有其他HPV类型的患病率均低于5%。结论:我们的研究结果表明HPV在扁桃体癌中很常见，并强调HPV 16的主导作用。
Human papillomavirus genotype distribution in tonsil cancers.
Background: The incidence of tonsil cancers has increased in several countries. French data on HPV prevalence in tonsil cancers are scarce. The objective of this study was thus to assess the overall and type specific HPV prevalence in tonsil histological samples.
Methods: This French retrospective multicenter study involved 12 centres located throughout the country. Were included 185 histological samples collected from year 2000 to 2009 with a validated diagnosis of tonsil invasive carcinomas. HPV prevalence was studied according to gender, age and histological type of cancer.
Results: Overall HPV prevalence was 57% in tonsil cancers. Mean age of diagnosis was comparable in HPV positive tonsils cases (60 ± 11.2) and HPV negative tonsil cases (59 ± 9.6). HPV prevalence was significantly higher in female than in male cases (28/35 versus 78/150 in tonsil cases, respectively, P = 0.003). About 53% of tonsil cases were infected by a single HPV type. Only eight (4%) samples were infected by more than one HPV type. Among HPV positive samples, HPV 16 was found in 89% of tonsil cases. All other HPV types had prevalence below 5%.
Conclusions: Our results indicate that HPV is common in tonsil carcinomas and emphasize the predominant role of HPV 16.
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