氢化可的松对大鼠蛛网膜下腔出血后脑盐消耗的抑制作用。

Methods and findings in experimental and clinical pharmacology Pub Date : 2010-12-01 DOI:10.1358/mf.2010.32.10.1561078

M Yoneko, Y Katayama, N Moro, J Kamei, J Kojima

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引用次数: 3

摘要

脑盐消耗(CSW)常伴发蛛网膜下腔出血(SAH)。CSW诱导过度钠尿和渗透性利尿，降低总血容量，加重脑血管痉挛，引起SAH后脑缺血。本研究考察了氢化可的松对SAH大鼠模型CSW的抑制作用。氢化可的松对CSW有抑制作用，因为氢化可的松以剂量依赖的方式抑制SAH发病后钠排泄和钠钾比的增加。我们认为氢化可的松是治疗SAH后CSW的有效药物。

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Inhibitory effect of hydrocortisone on cerebral salt wasting after subarachnoid hemorrhage in rats.

Cerebral salt wasting (CSW) frequently occurs concomitantly with subarachnoid hemorrhage (SAH). CSW induces excessive natriuresis and osmotic diuresis, reduces total blood volume, aggravates cerebral vasospasm and causes cerebral ischemia after SAH. This study examined the inhibitory effect of hydrocortisone on CSW in rat SAH models. Hydrocortisone had an inhibitory effect on CSW because hydrocortisone functioned in a dose-dependent manner to inhibit the increase in sodium excretion and sodium/potassium ratio after SAH onset. We conclude that hydrocortisone is a useful drug for the treatment of CSW after SAH.

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Methods and findings in experimental and clinical pharmacology 医学-药学

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>12 weeks