Maliheh Hashemi Nezhad , Norbert Drieschner , Sabrina Helms , Anke Meyer , Mahboobeh Tadayyon , Markus Klemke , Gazanfer Belge , Sabine Bartnitzke , Käte Burchardt , Christiane Frantzen , Ernst Heinrich Schmidt , Jörn Bullerdiek
{"title":"6p21重排在靶向HMGA1的子宫平滑肌瘤中的作用","authors":"Maliheh Hashemi Nezhad , Norbert Drieschner , Sabrina Helms , Anke Meyer , Mahboobeh Tadayyon , Markus Klemke , Gazanfer Belge , Sabine Bartnitzke , Käte Burchardt , Christiane Frantzen , Ernst Heinrich Schmidt , Jörn Bullerdiek","doi":"10.1016/j.cancergencyto.2010.08.005","DOIUrl":null,"url":null,"abstract":"<div><p>To quantify the expression of <em>HMGA1</em> mRNA in uterine leiomyomas, the expression of <em>HMGA1</em> was analyzed in a series including tumors with aberrations of chromosome 6 (<em>n</em> = 7) and cytogenetically normal tumors (<em>n</em> = 8) as a control group by quantitative reverse transcriptase–polymerase chain reaction. The average expression level in the 6p21 group was found to be 5.6 times higher than that in the control group, and with one exception, all cases with 6p21 alteration revealed a high expression of <em>HMGA1</em> mRNA than cytogenetically normal tumors. Nevertheless, compared to fibroids with a normal karyotype, the upregulation of the <em>HMGA1</em> mRNA in these cases was much less strong than that of <em>HMGA2</em> mRNA in case of 12q14∼15 aberrations identified in previous studies.</p></div>","PeriodicalId":55596,"journal":{"name":"Cancer Genetics and Cytogenetics","volume":"203 2","pages":"Pages 247-252"},"PeriodicalIF":0.0000,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cancergencyto.2010.08.005","citationCount":"35","resultStr":"{\"title\":\"6p21 rearrangements in uterine leiomyomas targeting HMGA1\",\"authors\":\"Maliheh Hashemi Nezhad , Norbert Drieschner , Sabrina Helms , Anke Meyer , Mahboobeh Tadayyon , Markus Klemke , Gazanfer Belge , Sabine Bartnitzke , Käte Burchardt , Christiane Frantzen , Ernst Heinrich Schmidt , Jörn Bullerdiek\",\"doi\":\"10.1016/j.cancergencyto.2010.08.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>To quantify the expression of <em>HMGA1</em> mRNA in uterine leiomyomas, the expression of <em>HMGA1</em> was analyzed in a series including tumors with aberrations of chromosome 6 (<em>n</em> = 7) and cytogenetically normal tumors (<em>n</em> = 8) as a control group by quantitative reverse transcriptase–polymerase chain reaction. The average expression level in the 6p21 group was found to be 5.6 times higher than that in the control group, and with one exception, all cases with 6p21 alteration revealed a high expression of <em>HMGA1</em> mRNA than cytogenetically normal tumors. Nevertheless, compared to fibroids with a normal karyotype, the upregulation of the <em>HMGA1</em> mRNA in these cases was much less strong than that of <em>HMGA2</em> mRNA in case of 12q14∼15 aberrations identified in previous studies.</p></div>\",\"PeriodicalId\":55596,\"journal\":{\"name\":\"Cancer Genetics and Cytogenetics\",\"volume\":\"203 2\",\"pages\":\"Pages 247-252\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.cancergencyto.2010.08.005\",\"citationCount\":\"35\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Genetics and Cytogenetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165460810004462\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Genetics and Cytogenetics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165460810004462","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
6p21 rearrangements in uterine leiomyomas targeting HMGA1
To quantify the expression of HMGA1 mRNA in uterine leiomyomas, the expression of HMGA1 was analyzed in a series including tumors with aberrations of chromosome 6 (n = 7) and cytogenetically normal tumors (n = 8) as a control group by quantitative reverse transcriptase–polymerase chain reaction. The average expression level in the 6p21 group was found to be 5.6 times higher than that in the control group, and with one exception, all cases with 6p21 alteration revealed a high expression of HMGA1 mRNA than cytogenetically normal tumors. Nevertheless, compared to fibroids with a normal karyotype, the upregulation of the HMGA1 mRNA in these cases was much less strong than that of HMGA2 mRNA in case of 12q14∼15 aberrations identified in previous studies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
