干扰素治疗丙型肝炎感染:一个历史的观点。

Hepatitis research and treatment Pub Date : 2010-01-01 Epub Date: 2010-09-06 DOI:10.1155/2010/323926
Robert M Friedman, Sara Contente
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引用次数: 19

摘要

干扰素于1957年首次被描述,但直到他们发现足够数量的干扰素可用于治疗丙型肝炎病毒(HCV)感染34年后,临床医生才对干扰素-α(IFN-α)治疗该疾病的有效性的基础有了极好的了解。当干扰素-α与抗病毒病毒利巴韦林互补时,干扰素-α的治疗更有效,并且IFN-α与聚乙二醇偶联形成聚乙二醇干扰素。在不久的将来,干扰素-α治疗丙型肝炎可能涉及目前正在开发的新的抗丙型肝炎药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment of hepatitis C infections with interferon: a historical perspective.

Interferons were first described in 1957, but it was not until 34 years after their discovery that sufficient quantities of it were available for treatment of hepatitis C virus (HCV) infections, Clinicians now have an excellent understanding of the basis for the effectiveness of interferon alpha (IFN-α) in the therapy of this disease. Treatment with IFN-α is more efficient when it complemented by the antiviral ribavirin and the IFN-α is conjugated with polyethylene glycol to form peginterferon. In the near future treatment of HCV with IFN-α may involve new anti-HCV agents that are currently under development.

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