{"title":"蛋白激酶C定位的高度特异性调节剂:在心力衰竭中的应用","authors":"Nir Qvit, Daria Mochly-Rosen","doi":"10.1016/j.ddmec.2010.07.001","DOIUrl":null,"url":null,"abstract":"<div><p><span>Heart failure (HF) in which the blood supply does not match the body's needs, affects 10% of the population over 65 years old. The </span>protein kinase C (PKC) family of kinases has a key role in normal and disease states. Here we discuss the role of PKC in HF and focus on the use of specific PKC regulators to identify the mechanism leading to this pathology and potential leads for therapeutics.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 2","pages":"Pages e87-e93"},"PeriodicalIF":0.0000,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.07.001","citationCount":"28","resultStr":"{\"title\":\"Highly specific modulators of protein kinase C localization: applications to heart failure\",\"authors\":\"Nir Qvit, Daria Mochly-Rosen\",\"doi\":\"10.1016/j.ddmec.2010.07.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Heart failure (HF) in which the blood supply does not match the body's needs, affects 10% of the population over 65 years old. The </span>protein kinase C (PKC) family of kinases has a key role in normal and disease states. Here we discuss the role of PKC in HF and focus on the use of specific PKC regulators to identify the mechanism leading to this pathology and potential leads for therapeutics.</p></div>\",\"PeriodicalId\":72843,\"journal\":{\"name\":\"Drug discovery today. Disease mechanisms\",\"volume\":\"7 2\",\"pages\":\"Pages e87-e93\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.07.001\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug discovery today. Disease mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1740676510000118\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676510000118","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Highly specific modulators of protein kinase C localization: applications to heart failure
Heart failure (HF) in which the blood supply does not match the body's needs, affects 10% of the population over 65 years old. The protein kinase C (PKC) family of kinases has a key role in normal and disease states. Here we discuss the role of PKC in HF and focus on the use of specific PKC regulators to identify the mechanism leading to this pathology and potential leads for therapeutics.
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