亚硝酸钠对猪控制出血模型中与HBOC-201相关的血管活性的剂量反应。

Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2011-08-01 Epub Date: 2010-12-06 DOI:10.3109/10731199.2010.533126

Françoise Arnaud, Anke H Scultetus, Bobby Kim, Ashraful Haque, Biswajit Saha, Savita Nigam, Paula Moon-Massat, Charles Auker, Richard McCarron, Daniel Freilich

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引用次数: 11

摘要

在55% EBV出血猪模型中评估亚硝酸钠(NaNO(2))减轻HBOC-201引起的血压升高的效果。动物通过3次10 ml/kg的HBOC-201或Hextend(含或不含NaNO)输注复苏(2)。2小时检测所有生命体征、凝血及血液化学。首次注入10.8 μmol/kg NaNO(2)后，hboc -201血管收缩力减弱。最高3nano(2)剂量完全消除，但观察到副作用。纳米没有降低血小板功能(2)。纳米(2)降低HBOC-201血管活性的能力是短暂的，10.8 μmol/kg纳米(2)似乎是进一步研究可以接受的剂量。

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Dose response of sodium nitrite on vasoactivity associated with HBOC-201 in a swine model of controlled hemorrhage.

Sodium nitrite (NaNO(2)) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three 10 ml/kg infusions of either HBOC-201 or Hextend with and without NaNO(2). All vital signs, coagulation and blood chemistry were measured for 2 hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8 μmol/kg NaNO(2) infusion. Complete abolition was obtained with the highest 3 NaNO(2) dose, but side effects were observed. There was no reduction in platelet function due to NaNO(2). NaNO(2) ability to reduce HBOC-201 vasoactivity was transient and 10.8 μmol/kg NaNO(2) seems an acceptable dose for further investigation.

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来源期刊

Artificial cells, blood substitutes, and immobilization biotechnology 工程技术-材料科学：生物材料

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6-12 weeks