京都大学10年口腔癌单一机构治疗经验。

Morimasa Kitamura, Shigeru Hirano, Ichiro Tateya, Shinpei Kada, Seiji Ishikawa, Tomoko Kanda, Ryo Asato, Juichi Ito
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引用次数: 3

摘要

结论:患者的预后与诊断时的初始阶段有关。提示早期诊断和治疗是改善口腔癌患者预后的最重要因素。辅助治疗也有必要改善晚期病例的局部控制。目的:更新口腔癌的治疗结果。方法:2000-2008年在京都大学附属医院接受治疗的口腔癌患者129例。I期34例,II期27例,III期15例,IVa期42例,IVb期1例。3例II期患者行近距离放射治疗。3例为III期,5例为IV期。随访时间12 ~ 96个月(平均30个月)。结果:5年累积总生存率和疾病特异性生存率分别为74.5%和75.3%。DSS I期为86.2%,II期为91.6%,III期为70.7%,IVa期为60.2%,IVb期为0%。DSS预后较差,结节状态较晚期。129例中32例局部复发,其中局部复发8例,淋巴结复发18例,咽后淋巴结转移1例,局部及淋巴结复发5例。对22例局部复发的患者行挽救手术加/不加术后放疗,其中7例存活。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ten years single institutional experience of treatment for oral cancer in Kyoto University.

Conclusions: The prognosis of patients was related to the initial stage at diagnosis. These results suggest that early diagnosis and treatment are the most important factors to improve the prognosis in oral cancer patients. Adjuvant treatment is also warranted to improve locoregional control of advanced cases.

Objectives: To update the therapeutic outcome of oral cancer.

Methods: In all, 129 cases with oral cancer were treated at Kyoto University Hospital during 2000-2008. Surgery with/without irradiation was performed for 34 cases in stage I, 27 in stage II, 15 in stage III, 42 in stage IVa, and 1 case in stage IVb. Brachytherapy was performed for three cases in stage II. Definitive radiotherapy was performed for three cases in stage III and five cases in stage IV. The follow-up period varied from 12 to 96 months (mean 30 months).

Results: The 5-year cumulative overall and disease-specific survival (DSS) rates were 74.5% and 75.3%. DSS was 86.2% in stage I, 91.6% in stage II, 70.7% in stage III, 60.2% in stage IVa, and 0% in stage IVb. DSS shows worse prognosis with advanced nodal status. Locoregional recurrence occurred in 32 of 129 cases, including local recurrence in 8 cases, nodal recurrence in 18, retropharyngeal node metastasis in 1, and local and nodal recurrence in 5 cases. Salvage operation with/without postoperative radiotherapy was performed for 22 cases with locoregional recurrence and 7 of them have survived.

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