地沙库特和赖诺普利治疗1例成人患者的非hiv坍缩性肾小球完全缓解。

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Clinical and Experimental Nephrology Pub Date : 2010-08-01 Epub Date: 2010-04-29 DOI:10.1007/s10157-010-0284-1
Jorge Vega, Francisco Javier Guarda, Helmuth Goecke, Gonzalo P Méndez
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引用次数: 2

摘要

塌陷性肾小球病是局灶性节段性肾小球硬化的一种形式,通常与HIV-1感染有关,其特点是预后差,几乎不可避免地发展为终末期肾病。其病理特征包括肾小球塌陷、足细胞肥大和增生、假月牙。本病例报告显示了一名58岁的非hiv特发性塌陷性肾小球病患者的演变,他表现出严重的肾病综合征和肾功能不全,并接受了赖诺普利和地氮唑治疗,后者是一种合成皮质类固醇,比强的松具有更少的美容效果和葡萄糖和骨代谢并发症。在不到两年的治疗后,患者肾功能完全恢复,尿中蛋白排泄范围正常。在停用类固醇三年后,患者的肾病综合征没有复发。目前还没有证实的治疗坍缩性肾小球病的方法,本病例强调了治疗这种疾病的另一种方法,几乎没有继发性影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Complete remission of non-HIV collapsing glomerulopathy with deflazacort and lisinopril in an adult patient.

Collapsing glomerulopathy is a form of focal segmental glomerulosclerosis that is usually associated with HIV-1 infection, and is characterized by its poor prognosis and almost inevitable progression to end-stage renal disease. Its pathological features include collapsed glomeruli, podocyte hypertrophy and hyperplasia, and pseudocrescents. This case report shows the evolution of a 58-year-old patient with non-HIV idiopathic collapsing glomerulopathy who presented with severe nephrotic syndrome and renal insufficiency and was treated with lisinopril and deflazacort, a synthetic corticosteroid that has shown fewer cosmetic effects and glucose and bone metabolism complications than prednisone. The patient responded with full recovery of renal function and normal range of protein excreted in urine after less than two years of treatment. The patient has not suffered a recurrence of his nephrotic syndrome after three years of steroid withdrawal. There is no proven therapy for collapsing glomerulopathy, and this case highlights an alternative for treating this disease with few secondary effects.

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来源期刊
Clinical and Experimental Nephrology
Clinical and Experimental Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.10
自引率
4.30%
发文量
135
审稿时长
4-8 weeks
期刊介绍: Clinical and Experimental Nephrology is a peer-reviewed monthly journal, officially published by the Japanese Society of Nephrology (JSN) to provide an international forum for the discussion of research and issues relating to the study of nephrology. Out of respect for the founders of the JSN, the title of this journal uses the term “nephrology,” a word created and brought into use with the establishment of the JSN (Japanese Journal of Nephrology, Vol. 2, No. 1, 1960). The journal publishes articles on all aspects of nephrology, including basic, experimental, and clinical research, so as to share the latest research findings and ideas not only with members of the JSN, but with all researchers who wish to contribute to a better understanding of recent advances in nephrology. The journal is unique in that it introduces to an international readership original reports from Japan and also the clinical standards discussed and agreed by JSN.
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