Keren Shi , Xiangming Liang , Mingming Li , Zhenhua Zhai , Ying Liu , Xiaoyan Shan , Yang Ma , Qianqian Gan , Huiqin Yao
{"title":"基于聚(N, N-二乙基丙烯酰胺)水凝胶膜的异烟肼药物逻辑体系的构建","authors":"Keren Shi , Xiangming Liang , Mingming Li , Zhenhua Zhai , Ying Liu , Xiaoyan Shan , Yang Ma , Qianqian Gan , Huiqin Yao","doi":"10.1016/j.snr.2023.100147","DOIUrl":null,"url":null,"abstract":"<div><p>In this work, poly(<em>N,N</em>-diethylacrylamide) (PDEA) hydrogel films were polymerized on glassy carbon (GC) electrode surface, and isoniazid (INH) was chosen as an electroactive pharmaceutical molecule probe, aiming to investigate the switchable electrochemical behaviors of INH. Determining the contents of INH tablets under different external stimuli conditions and constructing its logic gate computing systems. The triple-sensitive electrochemical CV behaviors of INH on this film system toward pH, temperature and salt concentration were observed and explored. Thus, a 3-input/8-output combinational pharmaceutical logic gate network and a 3-to-8 decoder were designed and constructed based on the stimulus-responsive characteristics of the electrochemical response of INH on PDEA hydrogel-modified electrodes. Besides, the relationship between the oxidation peak current (<em>I</em><sub>pa</sub>) and concentration of INH (<em>C</em><sub>INH</sub>) was studied by the differential pulse voltammetry (DPV) method. Apply this film system, and the INH tablets could be switchable detected. The construction of the logic-gate computing system based on isoniazid drug molecule may provide a novel approach and model to design new style drug sensors, which might be applied to intelligent medical diagnostics and drug release.</p></div>","PeriodicalId":426,"journal":{"name":"Sensors and Actuators Reports","volume":null,"pages":null},"PeriodicalIF":6.5000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Construction of isoniazid pharmaceutical logic system based on poly(N, N-diethylacrylamide) hydrogel films\",\"authors\":\"Keren Shi , Xiangming Liang , Mingming Li , Zhenhua Zhai , Ying Liu , Xiaoyan Shan , Yang Ma , Qianqian Gan , Huiqin Yao\",\"doi\":\"10.1016/j.snr.2023.100147\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this work, poly(<em>N,N</em>-diethylacrylamide) (PDEA) hydrogel films were polymerized on glassy carbon (GC) electrode surface, and isoniazid (INH) was chosen as an electroactive pharmaceutical molecule probe, aiming to investigate the switchable electrochemical behaviors of INH. Determining the contents of INH tablets under different external stimuli conditions and constructing its logic gate computing systems. The triple-sensitive electrochemical CV behaviors of INH on this film system toward pH, temperature and salt concentration were observed and explored. Thus, a 3-input/8-output combinational pharmaceutical logic gate network and a 3-to-8 decoder were designed and constructed based on the stimulus-responsive characteristics of the electrochemical response of INH on PDEA hydrogel-modified electrodes. Besides, the relationship between the oxidation peak current (<em>I</em><sub>pa</sub>) and concentration of INH (<em>C</em><sub>INH</sub>) was studied by the differential pulse voltammetry (DPV) method. Apply this film system, and the INH tablets could be switchable detected. The construction of the logic-gate computing system based on isoniazid drug molecule may provide a novel approach and model to design new style drug sensors, which might be applied to intelligent medical diagnostics and drug release.</p></div>\",\"PeriodicalId\":426,\"journal\":{\"name\":\"Sensors and Actuators Reports\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.5000,\"publicationDate\":\"2023-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sensors and Actuators Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666053923000103\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sensors and Actuators Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666053923000103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Construction of isoniazid pharmaceutical logic system based on poly(N, N-diethylacrylamide) hydrogel films
In this work, poly(N,N-diethylacrylamide) (PDEA) hydrogel films were polymerized on glassy carbon (GC) electrode surface, and isoniazid (INH) was chosen as an electroactive pharmaceutical molecule probe, aiming to investigate the switchable electrochemical behaviors of INH. Determining the contents of INH tablets under different external stimuli conditions and constructing its logic gate computing systems. The triple-sensitive electrochemical CV behaviors of INH on this film system toward pH, temperature and salt concentration were observed and explored. Thus, a 3-input/8-output combinational pharmaceutical logic gate network and a 3-to-8 decoder were designed and constructed based on the stimulus-responsive characteristics of the electrochemical response of INH on PDEA hydrogel-modified electrodes. Besides, the relationship between the oxidation peak current (Ipa) and concentration of INH (CINH) was studied by the differential pulse voltammetry (DPV) method. Apply this film system, and the INH tablets could be switchable detected. The construction of the logic-gate computing system based on isoniazid drug molecule may provide a novel approach and model to design new style drug sensors, which might be applied to intelligent medical diagnostics and drug release.
期刊介绍:
Sensors and Actuators Reports is a peer-reviewed open access journal launched out from the Sensors and Actuators journal family. Sensors and Actuators Reports is dedicated to publishing new and original works in the field of all type of sensors and actuators, including bio-, chemical-, physical-, and nano- sensors and actuators, which demonstrates significant progress beyond the current state of the art. The journal regularly publishes original research papers, reviews, and short communications.
For research papers and short communications, the journal aims to publish the new and original work supported by experimental results and as such purely theoretical works are not accepted.