分析毒理学。

EXS Pub Date : 2010-01-01 DOI:10.1007/978-3-7643-8338-1_9

Hans H Maurer

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引用次数: 1

摘要

本文综述了生物样品中药物、毒物及其代谢物的筛选、鉴定和定量的程序，以及相应的后处理程序。气相色谱-质谱法和液相色谱-质谱法是目前分析毒理学中最常用的方法。讨论了最合适的生物样品的选择，例如，死前/死后血液、尿液或组织或替代基质，如毛发、汗液和口服液、指甲或胎粪。文中还讨论了质量控制的重要性以及分析结果解释的可能性和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analytical toxicology.

This paper reviews procedures for screening, identification and quantification of drugs, poisons and their metabolites in biosamples, and the corresponding work-up procedures. Gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry are mostly used today in analytical toxicology. Selection of the most appropriate biosample, e.g., ante/postmortem blood, urine, or tissues or alternative matrices like hair, sweat and oral fluid, nails or meconium, is discussed. The importance of quality control and possibilities and limitations of interpretation of the analytical result are also discussed.

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EXS

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