M. de Lourdes González-Hernández, D. Godínez-Hernández, R. A. Bobadilla-Lugo, P. López-Sánchez
{"title":"血管紧张素ii型1受体(AT1R)和α - 1d肾上腺素受体在妊娠高血压期间形成异源二聚体","authors":"M. de Lourdes González-Hernández, D. Godínez-Hernández, R. A. Bobadilla-Lugo, P. López-Sánchez","doi":"10.1111/j.1474-8673.2009.00446.x","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p> <b>1</b> Pregnancy courses with low response to angiotensin II and adrenergic agonists. In preeclampsia, both effects are reverted. It is known that angiotensin II regulates adrenergic system. It is not known, however, the interaction between both systems receptors.</p>\n <p> <b>2</b> Our aim was to study if AT<sub>1</sub>R and α1D adrenoceptor heterodimerize in preeclampsia.</p>\n <p> <b>3</b> We used subrenal aorctic coarctation in pregnant rats. Aortic tissues were prepared for confocal imaging and coimmunoprecipitated for α1D and AT<sub>1</sub> receptors.</p>\n <p> <b>4</b> We found that AT<sub>1</sub>R and α1D adrenoceptor heterodimerize in both, healthy and preeclamptic groups. In healthy pregnant rats, heterodimer is barely detected. In preeclamptic rats however, we found higher heterodimerization.</p>\n <p> <b>5</b> These results suggest that AT<sub>1</sub>R and α1D -adrenoceptor may form heterodimers, and may play a role in preeclampsia.</p>\n </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2010-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1474-8673.2009.00446.x","citationCount":"29","resultStr":"{\"title\":\"Angiotensin-II type 1 receptor (AT1R) and alpha-1D adrenoceptor form a heterodimer during pregnancy-induced hypertension\",\"authors\":\"M. de Lourdes González-Hernández, D. Godínez-Hernández, R. A. Bobadilla-Lugo, P. López-Sánchez\",\"doi\":\"10.1111/j.1474-8673.2009.00446.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p> <b>1</b> Pregnancy courses with low response to angiotensin II and adrenergic agonists. In preeclampsia, both effects are reverted. It is known that angiotensin II regulates adrenergic system. It is not known, however, the interaction between both systems receptors.</p>\\n <p> <b>2</b> Our aim was to study if AT<sub>1</sub>R and α1D adrenoceptor heterodimerize in preeclampsia.</p>\\n <p> <b>3</b> We used subrenal aorctic coarctation in pregnant rats. Aortic tissues were prepared for confocal imaging and coimmunoprecipitated for α1D and AT<sub>1</sub> receptors.</p>\\n <p> <b>4</b> We found that AT<sub>1</sub>R and α1D adrenoceptor heterodimerize in both, healthy and preeclamptic groups. In healthy pregnant rats, heterodimer is barely detected. In preeclamptic rats however, we found higher heterodimerization.</p>\\n <p> <b>5</b> These results suggest that AT<sub>1</sub>R and α1D -adrenoceptor may form heterodimers, and may play a role in preeclampsia.</p>\\n </div>\",\"PeriodicalId\":100151,\"journal\":{\"name\":\"Autonomic and Autacoid Pharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1474-8673.2009.00446.x\",\"citationCount\":\"29\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Autonomic and Autacoid Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/j.1474-8673.2009.00446.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autonomic and Autacoid Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1474-8673.2009.00446.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Angiotensin-II type 1 receptor (AT1R) and alpha-1D adrenoceptor form a heterodimer during pregnancy-induced hypertension
1 Pregnancy courses with low response to angiotensin II and adrenergic agonists. In preeclampsia, both effects are reverted. It is known that angiotensin II regulates adrenergic system. It is not known, however, the interaction between both systems receptors.
2 Our aim was to study if AT1R and α1D adrenoceptor heterodimerize in preeclampsia.
3 We used subrenal aorctic coarctation in pregnant rats. Aortic tissues were prepared for confocal imaging and coimmunoprecipitated for α1D and AT1 receptors.
4 We found that AT1R and α1D adrenoceptor heterodimerize in both, healthy and preeclamptic groups. In healthy pregnant rats, heterodimer is barely detected. In preeclamptic rats however, we found higher heterodimerization.
5 These results suggest that AT1R and α1D -adrenoceptor may form heterodimers, and may play a role in preeclampsia.
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