细胞周期检查点的本质:事实与谬误。

Alexey Khodjakov, Conly L Rieder
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引用次数: 63

摘要

检查点控制的概念彻底改变了我们对细胞周期的理解。在这里,我们重新审视检查点的定义特征,并认为未能正确理解这一概念会导致对实验结果的误解。我们使用有丝分裂检查点来说明由于不遵守严格的定义和精确的术语而产生的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The nature of cell-cycle checkpoints: facts and fallacies.

The nature of cell-cycle checkpoints: facts and fallacies.

The nature of cell-cycle checkpoints: facts and fallacies.

The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading to misinterpretation of experimental results. We illustrate, using the mitotic checkpoint, problems that can arise from a failure to respect strict definitions and precise terminology.

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