RISC组装与功能的生化剖析。

Nucleic acids symposium series (2004) Pub Date : 2009-01-01 DOI:10.1093/nass/nrp008

Yukihide Tomari

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引用次数: 4

摘要

小沉默rna，包括小干扰rna (sirna)和microRNAs (miRNAs)，通过rna诱导沉默复合体(RISC)调控其靶基因的表达。RISC组装遵循复杂、有序的途径，并且RISC的功能多种多样，如切割、翻译抑制和靶细胞的死基化。我们最近展示了sirna和mirna是如何组装成不同类型的RISC的，以及它们的功能是如何不同的，使用果蝇作为模式生物。

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Biochemical dissection of RISC assembly and function.

Small silencing RNAs, including small interfering RNAs (siRNAs) and microRNAs (miRNAs), regulate expression of their target genes via RNA-induced silencing complex (RISC). RISC assembly follows complex, ordered pathways, and RISC function is as diverse as cleavage, translational repression, and deadenylation of the target. We have recently shown how siRNAs and miRNAs are assembled into distinct types of RISC, and how differently they function, using Drosophila as a model organism.

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Nucleic acids symposium series (2004)

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