具有二硫键的寡脱氧核苷酸的放射性单电子还原环化。

Nucleic acids symposium series (2004) Pub Date : 2009-01-01 DOI:10.1093/nass/nrp089

Eiji Matsumoto, Kazuhito Tanabe, Sei-ichi Nishimoto

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引用次数: 0

摘要

具有二硫键的寡脱氧核苷酸(ODNs)的单电子辐射还原以缺氧选择性方式诱导链交换反应。在这项研究中，我们试图将这种辐射分解反应应用于茎环结构的odn。低氧x射线照射到茎环结构odn的水溶液中，通过链内连接反应产生高产量的环化DNA。

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Radiolytic one-electron reductive cyclization of oligodeoxynucleotides possessing a disulfide bond.

Radiolytic one-electron reduction of oligodeoxynucleotides (ODNs) possessing a disulfide bond induced strand exchange reaction in a hypoxia selective manner. In this study, we attempted to apply this radiolytic reaction to stem-and-loop structured ODNs. Hypoxic X-irradiation to an aqueous solution of stem-and-loop structured ODNs produced a cyclized DNA in good yield via an intrastrand ligation reaction.

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Nucleic acids symposium series (2004)

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