研究蛋白质与核酸相互作用的化学方法。

Nucleic acids symposium series (2004) Pub Date : 2009-01-01 DOI:10.1093/nass/nrp022

Chuan He

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引用次数: 0

摘要

由于存在未修复的DNA损伤而导致的遗传变化的积累可导致癌症发展和其他疾病。核酸修饰在许多重要的生命过程中也起着关键作用。我们开发了一系列化学修饰的核酸类似物，可用于稳定蛋白质-核酸相互作用，用于结构和蛋白质组学研究。一些探针也被用于研究核酸-核酸相互作用。

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Chemical methods to study protein-nucleic acid interactions.

Accumulation of genetic changes due to the presence of unrepaired DNA lesions can lead to cancer development and other diseases. Nucleic acid modifications also play key roles in many essential life processes. We have developed a series of chemically modified nucleic acid analogues that can be applied to stabilize protein-nucleic acid interactions for structural and proteomic studies. Some of the probes have also been employed to study nucleic acid-nucleic acid interactions.

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Nucleic acids symposium series (2004)

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