基因组的“内在鱼”和脊椎动物的调控之谜。

Journal of Biology Pub Date : 2009-01-01 Epub Date: 2009-04-16 DOI:10.1186/jbiol131
John Malone, Brian Oliver
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引用次数: 2

摘要

到目前为止,关于从鱼类到人类的基因组信息如何编码相同组织的信息一次只出现一个基因。发表在本期杂志上的这项研究现在提供了跨越4.5亿年脊椎动物进化的20种脊椎动物组织的基因及其表达水平清单。它揭示了一组核心基因具有相似的组织表达模式,但没有共同的调控特征——这是一个基因表达悖论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The genomic 'inner fish' and a regulatory enigma in the vertebrates.

The genomic 'inner fish' and a regulatory enigma in the vertebrates.

The genomic 'inner fish' and a regulatory enigma in the vertebrates.

Information on how genomic information from fish to human encodes the same tissues has until now emerged one gene at a time. The study published in this issue now provides lists of genes and their expression levels for 20 vertebrate tissues spanning 450 million years of vertebrate evolution. It reveals a core set of genes with similar tissue-expression patterns yet no common regulatory signatures--a gene-expression paradox.

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