Monica J. Carson, J. Cameron Thrash, Barbara Walter
{"title":"神经炎症的细胞反应:白细胞、小胶质细胞和星形胶质细胞在神经元死亡和存活中的作用","authors":"Monica J. Carson, J. Cameron Thrash, Barbara Walter","doi":"10.1016/j.cnr.2006.09.004","DOIUrl":null,"url":null,"abstract":"<div><p><span>Neuroinflammation<span> is a complex integration of the responses of all cells present within the CNS, including the neurons, macroglia, </span></span>microglia<span><span> and the infiltrating leukocytes. The initiating insult, environmental factors, genetic background and age/past experiences all combine to modulate the integrated response of this complex neuroinflammatory circuit. Here, we explore how these factors interact to lead to either neuroprotective versus neurotoxic inflammatory responses. We specifically focus on microglia and astrocytic regulation of autoreactive </span>T cell responses.</span></p></div>","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2006-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cnr.2006.09.004","citationCount":"233","resultStr":"{\"title\":\"The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival\",\"authors\":\"Monica J. Carson, J. Cameron Thrash, Barbara Walter\",\"doi\":\"10.1016/j.cnr.2006.09.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Neuroinflammation<span> is a complex integration of the responses of all cells present within the CNS, including the neurons, macroglia, </span></span>microglia<span><span> and the infiltrating leukocytes. The initiating insult, environmental factors, genetic background and age/past experiences all combine to modulate the integrated response of this complex neuroinflammatory circuit. Here, we explore how these factors interact to lead to either neuroprotective versus neurotoxic inflammatory responses. We specifically focus on microglia and astrocytic regulation of autoreactive </span>T cell responses.</span></p></div>\",\"PeriodicalId\":87465,\"journal\":{\"name\":\"Clinical neuroscience research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.cnr.2006.09.004\",\"citationCount\":\"233\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical neuroscience research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1566277206000429\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical neuroscience research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1566277206000429","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival
Neuroinflammation is a complex integration of the responses of all cells present within the CNS, including the neurons, macroglia, microglia and the infiltrating leukocytes. The initiating insult, environmental factors, genetic background and age/past experiences all combine to modulate the integrated response of this complex neuroinflammatory circuit. Here, we explore how these factors interact to lead to either neuroprotective versus neurotoxic inflammatory responses. We specifically focus on microglia and astrocytic regulation of autoreactive T cell responses.