{"title":"吡格列酮对2型糖尿病患者一氧化氮合酶的影响","authors":"Kazuaki Nishio MD, PhD, Meiei Shigemitsu MD, Yusuke Kodama MD, Seiji Itoh MD, Noburu Konno MD, PhD, Ryuji Satoh MD, Takashi Katagiri MD, PhD, Youichi Kobayashi MD, PhD","doi":"10.1111/j.1559-4572.2008.00019.x","DOIUrl":null,"url":null,"abstract":"<p>The aim of this study was to evaluate the effect of pioglitazone on nitric oxide in patients with type 2 diabetes and coronary artery disease. Twenty-seven patients with coronary artery disease and diabetes mellitus who had received coronary stenting were eligible for the study. They were assigned to the no insulin resistance (NIR) group, the insulin resistance (IR) group, and the pioglitazone group (30 mg once a day). Endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), tumor necrosis factor α (TNF-α), interleukin-6, leptin, and adiponectin were measured. In the pioglitazone group, eNOS, iNOS, and leptin were significantly lower and adiponectin was significantly higher than those in the IR group. Stepwise multiple regression analyses showed that eNOS correlated with TNF-α and iNOS correlated with leptin and TNF-α. Leptin was the strongest predictor of iNOS. Treatment with pioglitazone significantly reduced eNOS and iNOS by improving adipocytokine levels.</p>","PeriodicalId":87477,"journal":{"name":"Journal of the cardiometabolic syndrome","volume":"3 4","pages":"200-204"},"PeriodicalIF":0.0000,"publicationDate":"2008-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1559-4572.2008.00019.x","citationCount":"8","resultStr":"{\"title\":\"The Effect of Pioglitazone on Nitric Oxide Synthase in Patients With Type 2 Diabetes Mellitus\",\"authors\":\"Kazuaki Nishio MD, PhD, Meiei Shigemitsu MD, Yusuke Kodama MD, Seiji Itoh MD, Noburu Konno MD, PhD, Ryuji Satoh MD, Takashi Katagiri MD, PhD, Youichi Kobayashi MD, PhD\",\"doi\":\"10.1111/j.1559-4572.2008.00019.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The aim of this study was to evaluate the effect of pioglitazone on nitric oxide in patients with type 2 diabetes and coronary artery disease. Twenty-seven patients with coronary artery disease and diabetes mellitus who had received coronary stenting were eligible for the study. They were assigned to the no insulin resistance (NIR) group, the insulin resistance (IR) group, and the pioglitazone group (30 mg once a day). Endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), tumor necrosis factor α (TNF-α), interleukin-6, leptin, and adiponectin were measured. In the pioglitazone group, eNOS, iNOS, and leptin were significantly lower and adiponectin was significantly higher than those in the IR group. Stepwise multiple regression analyses showed that eNOS correlated with TNF-α and iNOS correlated with leptin and TNF-α. Leptin was the strongest predictor of iNOS. Treatment with pioglitazone significantly reduced eNOS and iNOS by improving adipocytokine levels.</p>\",\"PeriodicalId\":87477,\"journal\":{\"name\":\"Journal of the cardiometabolic syndrome\",\"volume\":\"3 4\",\"pages\":\"200-204\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-11-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1559-4572.2008.00019.x\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the cardiometabolic syndrome\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/j.1559-4572.2008.00019.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the cardiometabolic syndrome","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1559-4572.2008.00019.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Effect of Pioglitazone on Nitric Oxide Synthase in Patients With Type 2 Diabetes Mellitus
The aim of this study was to evaluate the effect of pioglitazone on nitric oxide in patients with type 2 diabetes and coronary artery disease. Twenty-seven patients with coronary artery disease and diabetes mellitus who had received coronary stenting were eligible for the study. They were assigned to the no insulin resistance (NIR) group, the insulin resistance (IR) group, and the pioglitazone group (30 mg once a day). Endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), tumor necrosis factor α (TNF-α), interleukin-6, leptin, and adiponectin were measured. In the pioglitazone group, eNOS, iNOS, and leptin were significantly lower and adiponectin was significantly higher than those in the IR group. Stepwise multiple regression analyses showed that eNOS correlated with TNF-α and iNOS correlated with leptin and TNF-α. Leptin was the strongest predictor of iNOS. Treatment with pioglitazone significantly reduced eNOS and iNOS by improving adipocytokine levels.
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