利用代谢组学发现药物开发和转化医学的生物标志物。

H C Keun
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引用次数: 9

摘要

目前迫切需要更好的生物标志物,特别是在药物开发和疾病检测和管理的背景下。生物标志物发现和开发领域的许多研究人员已经转向“组学”科学作为解决这些需求的一种方式。代谢分析或代谢组学定义了代谢表型,并提供了具有更好的有效翻译潜力的新型生物标志物的来源。这篇综述将讨论代谢组学背后的广泛理念和动机,并举例说明与药物开发和患者管理相关的应用。特别关注代谢组学在毒理学和癌症研究中发现生物标志物的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomarker discovery for drug development and translational medicine using metabonomics.

There exists at present an urgent desire for better biomarkers, especially in the context of pharmaceutical drug development and in the detection and management of disease. Many researchers in the area of biomarker discovery and development have turned to the "-omics" sciences as a way of addressing these needs. Metabolic profiling, or metabonomics, defines the metabolic phenotype and offers a source of novel biomarkers that have better potential to translate effectively. This review will discuss the broad philosophy and motivations behind metabonomics, and illustrate the case with applications relevant to pharmaceutical development and patient management. Particular focus will be paid to the potential of metabonomics to contribute to biomarker discovery in toxicology and cancer research.

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