Ozgul Topal, Selim S Erbek, Halil Kiyici, Ozcan Cakmak
{"title":"金属蛋白酶MMP-2和MMP-9在鼻后鼻息肉中的表达。","authors":"Ozgul Topal, Selim S Erbek, Halil Kiyici, Ozcan Cakmak","doi":"10.2500/ajr.2008.22.3183","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Matrix metalloproteinase (MMP) 2 and MMP-9 are known to cleave specifically type 4 collagen, which is a major structural component of basement membrane. This is an early step of inflammation. Because of this property they have been studied in chronic sinonasal disorders. The aim of this study was to determine the MMP-2 and MMP-9 expressions in an antrochoanal polyp (ACP).</p><p><strong>Methods: </strong>We examined tissue samples from 10 ACPs, 10 diffuse nasal polyps, and 10 control nasal mucosa (CM) by immunohistochemistry for MMP-2 and MMP-9 expression.</p><p><strong>Results: </strong>Most of epithelial and endothelial cells showed positive immunostaining for MMP-2 and MMP-9 in all tissue samples. MMP-2 staining of inflammatory cells showed no difference among the groups (p > 0.05). On the other hand, MMP-9+ inflammatory cells were found to be significantly increased in ACP and diffuse nasal polyps when compared with CM (p < 0.05).</p><p><strong>Conclusion: </strong>MMP-9-expressing inflammatory cells could play a role in the pathophysiology of ACP as well as nasal polyps.</p>","PeriodicalId":72175,"journal":{"name":"American journal of rhinology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2008-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ajr.2008.22.3183","citationCount":"21","resultStr":"{\"title\":\"Expression of metalloproteinases MMP-2 and MMP-9 in antrochoanal polyps.\",\"authors\":\"Ozgul Topal, Selim S Erbek, Halil Kiyici, Ozcan Cakmak\",\"doi\":\"10.2500/ajr.2008.22.3183\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Matrix metalloproteinase (MMP) 2 and MMP-9 are known to cleave specifically type 4 collagen, which is a major structural component of basement membrane. This is an early step of inflammation. Because of this property they have been studied in chronic sinonasal disorders. The aim of this study was to determine the MMP-2 and MMP-9 expressions in an antrochoanal polyp (ACP).</p><p><strong>Methods: </strong>We examined tissue samples from 10 ACPs, 10 diffuse nasal polyps, and 10 control nasal mucosa (CM) by immunohistochemistry for MMP-2 and MMP-9 expression.</p><p><strong>Results: </strong>Most of epithelial and endothelial cells showed positive immunostaining for MMP-2 and MMP-9 in all tissue samples. MMP-2 staining of inflammatory cells showed no difference among the groups (p > 0.05). On the other hand, MMP-9+ inflammatory cells were found to be significantly increased in ACP and diffuse nasal polyps when compared with CM (p < 0.05).</p><p><strong>Conclusion: </strong>MMP-9-expressing inflammatory cells could play a role in the pathophysiology of ACP as well as nasal polyps.</p>\",\"PeriodicalId\":72175,\"journal\":{\"name\":\"American journal of rhinology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.2500/ajr.2008.22.3183\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of rhinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2500/ajr.2008.22.3183\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of rhinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2500/ajr.2008.22.3183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Expression of metalloproteinases MMP-2 and MMP-9 in antrochoanal polyps.
Background: Matrix metalloproteinase (MMP) 2 and MMP-9 are known to cleave specifically type 4 collagen, which is a major structural component of basement membrane. This is an early step of inflammation. Because of this property they have been studied in chronic sinonasal disorders. The aim of this study was to determine the MMP-2 and MMP-9 expressions in an antrochoanal polyp (ACP).
Methods: We examined tissue samples from 10 ACPs, 10 diffuse nasal polyps, and 10 control nasal mucosa (CM) by immunohistochemistry for MMP-2 and MMP-9 expression.
Results: Most of epithelial and endothelial cells showed positive immunostaining for MMP-2 and MMP-9 in all tissue samples. MMP-2 staining of inflammatory cells showed no difference among the groups (p > 0.05). On the other hand, MMP-9+ inflammatory cells were found to be significantly increased in ACP and diffuse nasal polyps when compared with CM (p < 0.05).
Conclusion: MMP-9-expressing inflammatory cells could play a role in the pathophysiology of ACP as well as nasal polyps.
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