WELYSSA:一种使用小鼠单克隆抗体检测狂犬病疑似标本中溶血病毒核衣壳的简单工具。

Developments in biologicals Pub Date : 2008-01-01
G Xu, P Weber, Q Hu, H Xue, L Audry, C Li, J Wu, H Bourhy
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引用次数: 0

摘要

建立了一种基于单克隆抗体(MAb)的捕获酶联免疫吸附试验(ELISA),用于狂犬病疑似标本的诊断,使用来自不同地理来源和系统发育谱系的不同溶血病毒基因型的原型病毒。它包括一组用于狂犬病诊断测试的1,660个标本,与其他推荐的狂犬病诊断方法相比,发现具有高度特异性(99.9%)和敏感性(97.0%)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
WELYSSA: a simple tool using mouse monoclonal antibodies for the detection of lyssavirus nucleocapsid in rabies suspected specimens.

A Monoclonal antibody (MAb)-based capture enzyme-linked immunosorbent assay (ELISA) named WELYSSA was developed for the diagnosis of rabies suspected specimens using prototype viruses from the different genotypes of lyssavirus and from various geographic origins and phylogenetic lineages. It included a panel of 1,660 specimens received for rabies diagnostic testing, and was found to be highly specific (99.9%) and sensitive (97.0%) when compared to other recommended rabies diagnostic methods.

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