鞘氨醇激酶和鞘氨醇-1-磷酸在内皮细胞生物学调节中的作用。

Vidya Limaye
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引用次数: 29

摘要

鞘脂,特别是鞘磷脂激酶(SphK)及其产物鞘磷脂-1-磷酸(S1P),现在被认为在调节内皮细胞的许多关键过程中发挥重要作用。SphK1的激活在介导炎性细胞因子如肿瘤坏死因子(TNF)的内皮促炎作用中是必不可少的。此外,S1P调节内皮细胞的存活和增殖,以及它们进行细胞迁移的能力,这些都是血管生成的重要组成部分。因此,内皮的炎症和血管生成潜能在一定程度上受细胞内成分的调节,包括SphK1的活性和S1P的水平。本文综述了鞘磷脂通路,特别关注其与内皮细胞生物学的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of sphingosine kinase and sphingosine-1-phosphate in the regulation of endothelial cell biology.

Sphingolipids, in particular sphingosine kinase (SphK) and its product sphingosine-1-phosphate (S1P), are now recognized to play an important role in regulating many critical processes in endothelial cells. Activation of SphK1 is essential in mediating the endothelial proinflammatory effects of inflammatory cytokines such as tumor necrosis factor (TNF). In addition, S1P regulates the survival and proliferation of endothelial cells, as well as their ability to undergo cell migration, all essential components of angiogenesis. Thus the inflammatory and angiogenic potential of the endothelium is in part regulated by intracellular components including the activity of SphK1 and levels of S1P. Herein a review of the sphingomyelin pathway with a particular focus on its relevance to endothelial cell biology is presented.

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