Máfircio L A E Silva, Alberto F Neto, Silvia A Cardoso, Sérgio Albuquerque, Joseph Miller
{"title":"一些有机铁化合物的合成及体外杀锥虫活性评价。","authors":"Máfircio L A E Silva, Alberto F Neto, Silvia A Cardoso, Sérgio Albuquerque, Joseph Miller","doi":"10.1155/MBD.2002.329","DOIUrl":null,"url":null,"abstract":"Eight organo-iron ferrocene derivatives and arenocenium salts were prepared and evaluated by “in vitro” assay against one strain of Trypanosoma cruzi (Y). Six of the eight organo-iron compounds assayed, piperazinium diferrocenoate 1, η6-(o-xylene)-η5-(cyclopentadienyl) Iron(II) hexafluorophosphate 3, η6-(mesitylene)-η5-(cyclopentadienyl) iron(II) hexafluorphosphate 5, η6-(durene)-η5-(cyclopentadienyl) iron(II) hexafluorphosphate 6, η6-(ρ-chlorotoluene)-η5-(cyclopentadienyl) Iron(II) hexafluorphosphate 7 and η6-(chlorobenzene)-η5-(cyclopentadienyl) iron(II) picrate 8 , were poorly active in the “in vitro” assays. Only two compounds 1,1'–(N-pyperidinocarbonyl) ferrocene 2(IC50=2.4 μg/mL) and η6-(o-xylene)-η5(cyclopentadienyl) iron(II) picrate 4 (IC50=12.08 μg/mL), were more active. Thus, some of the compounds are promising to be used against Chagas' disease as a prophylactic agents.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 6","pages":"329-32"},"PeriodicalIF":0.0000,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2002.329","citationCount":"2","resultStr":"{\"title\":\"Synthesis and \\\"in Vitro\\\" Trypanocidal Activity Evaluation of Some Organo-iron Compounds.\",\"authors\":\"Máfircio L A E Silva, Alberto F Neto, Silvia A Cardoso, Sérgio Albuquerque, Joseph Miller\",\"doi\":\"10.1155/MBD.2002.329\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Eight organo-iron ferrocene derivatives and arenocenium salts were prepared and evaluated by “in vitro” assay against one strain of Trypanosoma cruzi (Y). Six of the eight organo-iron compounds assayed, piperazinium diferrocenoate 1, η6-(o-xylene)-η5-(cyclopentadienyl) Iron(II) hexafluorophosphate 3, η6-(mesitylene)-η5-(cyclopentadienyl) iron(II) hexafluorphosphate 5, η6-(durene)-η5-(cyclopentadienyl) iron(II) hexafluorphosphate 6, η6-(ρ-chlorotoluene)-η5-(cyclopentadienyl) Iron(II) hexafluorphosphate 7 and η6-(chlorobenzene)-η5-(cyclopentadienyl) iron(II) picrate 8 , were poorly active in the “in vitro” assays. Only two compounds 1,1'–(N-pyperidinocarbonyl) ferrocene 2(IC50=2.4 μg/mL) and η6-(o-xylene)-η5(cyclopentadienyl) iron(II) picrate 4 (IC50=12.08 μg/mL), were more active. Thus, some of the compounds are promising to be used against Chagas' disease as a prophylactic agents.\",\"PeriodicalId\":18452,\"journal\":{\"name\":\"Metal-Based Drugs\",\"volume\":\"8 6\",\"pages\":\"329-32\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/MBD.2002.329\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Metal-Based Drugs\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/MBD.2002.329\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metal-Based Drugs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/MBD.2002.329","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and "in Vitro" Trypanocidal Activity Evaluation of Some Organo-iron Compounds.
Eight organo-iron ferrocene derivatives and arenocenium salts were prepared and evaluated by “in vitro” assay against one strain of Trypanosoma cruzi (Y). Six of the eight organo-iron compounds assayed, piperazinium diferrocenoate 1, η6-(o-xylene)-η5-(cyclopentadienyl) Iron(II) hexafluorophosphate 3, η6-(mesitylene)-η5-(cyclopentadienyl) iron(II) hexafluorphosphate 5, η6-(durene)-η5-(cyclopentadienyl) iron(II) hexafluorphosphate 6, η6-(ρ-chlorotoluene)-η5-(cyclopentadienyl) Iron(II) hexafluorphosphate 7 and η6-(chlorobenzene)-η5-(cyclopentadienyl) iron(II) picrate 8 , were poorly active in the “in vitro” assays. Only two compounds 1,1'–(N-pyperidinocarbonyl) ferrocene 2(IC50=2.4 μg/mL) and η6-(o-xylene)-η5(cyclopentadienyl) iron(II) picrate 4 (IC50=12.08 μg/mL), were more active. Thus, some of the compounds are promising to be used against Chagas' disease as a prophylactic agents.
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