天然产物激发的多样性导向合成在药物发现中的应用。

Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques Pub Date : 2008-01-01 DOI:10.1007/978-3-7643-8595-8_3

Lisa A Marcaurelle, Charles W Johannes

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引用次数: 32

摘要

天然产物在许多药物的鉴定中发挥了关键作用。合成有机化学和组合化学策略，如多样性导向合成(DOS)使天然产物类化合物的合成成为可能。这些方法的结合既提高了天然产物的生物学特性，也提高了新化合物的鉴定。本文将回顾从天然产物中获取新化合物的多样性概念和策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Application of natural product-inspired diversity-oriented synthesis to drug discovery.

Natural products have played a critical role in the identification of numerous medicines. Synthetic organic chemistry and combinatorial chemistry strategies such as diversity-oriented synthesis (DOS) have enabled the synthesis of natural product-like compounds. The combination of these approaches has both improved the desired biological properties of natural products as well as the identification of novel compounds. Diversity concepts and strategies to access novel compounds inspired by natural products will be reviewed.

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Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques

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