{"title":"慢性阻塞性肺疾病的内皮功能障碍。","authors":"Leo Moro, Claudio Pedone, Simone Scarlata, Vincenzo Malafarina, Filippo Fimognari, Raffaele Antonelli-Incalzi","doi":"10.1177/0003319707306141","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases are prevalent in people with chronic obstructive pulmonary disease (COPD). We hypothesized that endothelial dysfunction could be a marker of the proatherogen status in COPD.</p><p><strong>Methods and results: </strong>We measured endothelial dysfunction by flow-mediated dilation (FMD) and after sublingual administration of nitroglycerin (nitrate-mediated dilation: NMD) in 44 COPD patients and 48 controls. Compared with controls COPD patients had worse mean FMD (5.4% vs 8.2%, P < .001) and NMD (12.0% vs 13.9%, P = .007). FMD was inversely related to FEV1/VC ratio (r = -0.327, P = .030). The negative association between COPD and FMD was confirmed after correction for potential confounders in a multiple linear regression model (beta = -0.019, P = .002). In the same model NMD (beta = 0.396, P < .001) was positively associated with FMD.</p><p><strong>Conclusions: </strong>Endothelial-dependent and, to a lesser extent, endothelial-independent dilations are significantly impaired in COPD, and the impairment is proportional to the severity of bronchial obstruction.</p>","PeriodicalId":8264,"journal":{"name":"Angiology","volume":"59 3","pages":"357-64"},"PeriodicalIF":2.6000,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0003319707306141","citationCount":"87","resultStr":"{\"title\":\"Endothelial dysfunction in chronic obstructive pulmonary disease.\",\"authors\":\"Leo Moro, Claudio Pedone, Simone Scarlata, Vincenzo Malafarina, Filippo Fimognari, Raffaele Antonelli-Incalzi\",\"doi\":\"10.1177/0003319707306141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cardiovascular diseases are prevalent in people with chronic obstructive pulmonary disease (COPD). We hypothesized that endothelial dysfunction could be a marker of the proatherogen status in COPD.</p><p><strong>Methods and results: </strong>We measured endothelial dysfunction by flow-mediated dilation (FMD) and after sublingual administration of nitroglycerin (nitrate-mediated dilation: NMD) in 44 COPD patients and 48 controls. Compared with controls COPD patients had worse mean FMD (5.4% vs 8.2%, P < .001) and NMD (12.0% vs 13.9%, P = .007). FMD was inversely related to FEV1/VC ratio (r = -0.327, P = .030). The negative association between COPD and FMD was confirmed after correction for potential confounders in a multiple linear regression model (beta = -0.019, P = .002). In the same model NMD (beta = 0.396, P < .001) was positively associated with FMD.</p><p><strong>Conclusions: </strong>Endothelial-dependent and, to a lesser extent, endothelial-independent dilations are significantly impaired in COPD, and the impairment is proportional to the severity of bronchial obstruction.</p>\",\"PeriodicalId\":8264,\"journal\":{\"name\":\"Angiology\",\"volume\":\"59 3\",\"pages\":\"357-64\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2008-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/0003319707306141\",\"citationCount\":\"87\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Angiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/0003319707306141\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2008/4/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/0003319707306141","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2008/4/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 87
摘要
背景:心血管疾病在慢性阻塞性肺疾病(COPD)患者中普遍存在。我们假设内皮功能障碍可能是COPD患者动脉粥样硬化状态的标志。方法和结果:我们通过血流介导的扩张(FMD)和舌下给药硝酸甘油(硝酸盐介导的扩张:NMD)测量了44例COPD患者和48例对照组的内皮功能障碍。与对照组相比，COPD患者的平均FMD (5.4% vs 8.2%， P < .001)和NMD (12.0% vs 13.9%， P = .007)更差。FMD与FEV1/VC比呈负相关(r = -0.327, P = 0.030)。在多元线性回归模型中校正潜在混杂因素后，证实COPD与FMD之间存在负相关(beta = -0.019, P = 0.002)。在同一模型中，NMD与FMD呈正相关(β = 0.396, P < 0.001)。结论:COPD患者的内皮依赖性扩张和较小程度的内皮非依赖性扩张均明显受损，且受损程度与支气管梗阻的严重程度成正比。
Endothelial dysfunction in chronic obstructive pulmonary disease.
Background: Cardiovascular diseases are prevalent in people with chronic obstructive pulmonary disease (COPD). We hypothesized that endothelial dysfunction could be a marker of the proatherogen status in COPD.
Methods and results: We measured endothelial dysfunction by flow-mediated dilation (FMD) and after sublingual administration of nitroglycerin (nitrate-mediated dilation: NMD) in 44 COPD patients and 48 controls. Compared with controls COPD patients had worse mean FMD (5.4% vs 8.2%, P < .001) and NMD (12.0% vs 13.9%, P = .007). FMD was inversely related to FEV1/VC ratio (r = -0.327, P = .030). The negative association between COPD and FMD was confirmed after correction for potential confounders in a multiple linear regression model (beta = -0.019, P = .002). In the same model NMD (beta = 0.396, P < .001) was positively associated with FMD.
Conclusions: Endothelial-dependent and, to a lesser extent, endothelial-independent dilations are significantly impaired in COPD, and the impairment is proportional to the severity of bronchial obstruction.
期刊介绍：
A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days
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