142例下咽癌预后因素的单因素和多因素研究

Masato Mochiki, Masashi Sugasawa, Ken-Ichi Nibu, Masao Asai, Kazunari Nakao, Takahiro Asakage
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引用次数: 11

摘要

结论:减少远处转移对于提高生存率至关重要。对于原发疾病晚期(T>2)以及淋巴结状态晚期(N>0或PLN>2)患者,应制定有效的辅助化疗方案。目的:本研究的目的是确定下咽癌的预后因素。患者和方法:回顾性分析142例未经治疗的患者;75%的病例为III期或IV期。116例(82%)患者接受手术切除作为主要治疗,26例(18%)患者接受主要放疗。结果:特定病因的5年精算生存率为46.3%。远处转移是最常见的(23%)失败原因,其次是局部复发(15%)和区域复发(13%)。Cox回归分析显示,影响病因特异性生存率的显著因素有N分型、T分型、病理淋巴结转移数(PLN)、淋巴浸润、手术切缘阳性。同样,T分类和PLN影响远处转移。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic factors for hypopharyngeal cancer: a univariate and multivariate study of 142 cases.

Conclusions: Reduction of distant metastases is essential for better survival. Effective adjuvant chemotherapy should be developed for patients with advanced primary disease (T>2) as well as for patients with advanced nodal status (N>0 or PLN>2).

Objectives: The aim of this study was to identify prognostic factors for hypopharyngeal cancer.

Patients and methods: In all, 142 previously untreated patients were analyzed retrospectively; 75% of the cases were stage III or IV. Surgical resection was administered as primary treatment to 116 of the patients (82%), while 26 patients (18%) underwent primary radiotherapy.

Results: The cause-specific 5-year actuarial survival was 46.3%. Distant metastases were the most frequent (23%) cause of failure, followed by local recurrence (15%), and regional recurrence (13%). Cox's regression analysis showed that the significant factors affecting cause-specific survival were N classification, T classification, number of pathological lymph node metastases (PLN), lymphatic invasion, and positive surgical margin. Similarly, T classification and PLN affected distant metastases.

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