{"title":"eIF2alpha对长期突触可塑性和记忆储存的翻译控制。","authors":"Mauro Costa-Mattioli, Nahum Sonenberg","doi":"10.1615/critrevneurobiol.v18.i1-2.190","DOIUrl":null,"url":null,"abstract":"Both long-lasting changes in synaptic function and long-term memory require gene expression. However, the molecular mechanisms by which gene expression is turned on are not fully understood. In this review, we highlight the role of the eukaryotic initiation factor 2 alpha (eIF2alpha) signalling pathway in long-term synaptic plasticity and memory.","PeriodicalId":10778,"journal":{"name":"Critical reviews in neurobiology","volume":"18 1-2","pages":"187-95"},"PeriodicalIF":0.0000,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"21","resultStr":"{\"title\":\"Translational control of long-term synaptic plasticity and memory storage by eIF2alpha.\",\"authors\":\"Mauro Costa-Mattioli, Nahum Sonenberg\",\"doi\":\"10.1615/critrevneurobiol.v18.i1-2.190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Both long-lasting changes in synaptic function and long-term memory require gene expression. However, the molecular mechanisms by which gene expression is turned on are not fully understood. In this review, we highlight the role of the eukaryotic initiation factor 2 alpha (eIF2alpha) signalling pathway in long-term synaptic plasticity and memory.\",\"PeriodicalId\":10778,\"journal\":{\"name\":\"Critical reviews in neurobiology\",\"volume\":\"18 1-2\",\"pages\":\"187-95\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Critical reviews in neurobiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1615/critrevneurobiol.v18.i1-2.190\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical reviews in neurobiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1615/critrevneurobiol.v18.i1-2.190","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Translational control of long-term synaptic plasticity and memory storage by eIF2alpha.
Both long-lasting changes in synaptic function and long-term memory require gene expression. However, the molecular mechanisms by which gene expression is turned on are not fully understood. In this review, we highlight the role of the eukaryotic initiation factor 2 alpha (eIF2alpha) signalling pathway in long-term synaptic plasticity and memory.
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