Wenrong Dong, Xiaoming Li, Xiuying Lu, Bin Di, Jing Ma, Liping Cui
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[Expression of Survivin and its correlation with tumor angiogenesis in differentiated thyroid carcinomas].
Objective: To identify the expression of Survivin and its relationship with tumor angiogenesis in differentiated thyroid carcinomas.
Method: The expression of Survivin, VEGF and MVD were detected by immuno-histochemical staining (SP methods) in 47 differentiated thyroid carcinomas, 10 thyroid adenoma and 10 normal thyroid tissues and their content were measured by pathological image analysis system.
Result: The expression of Survivin and VEGF in differentiated thyroid carcinomas was 46.8% and 61.7%, respectively. No expression of Survivin was detected in thyroid adenoma and normal thyroid tissues. The expression of Survivin was significantly correlated with the expression of VEGF and MVD in differentiated thyroid carcinomas. The expression of Survivin was significantly associated with clinical stages, tumor complete capsule and lymph node metastasis.
Conclusion: The up-regulation of Survivin expression and its close relationship with angiogenesis may play an important role in carcinogenesis and development of differentiated thyroid carcinomas.
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