{"title":"[过量水杨酸钠注射对豚鼠耳蜗螺旋神经节细胞核因子- κ b蛋白表达的影响]。","authors":"Hong Lü, Lilian Wu, Ying Zeng","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To study the effect of sodium salicylate on the nuclear factor-kappaB (NF-kappaB) protein expression in spiral ganglion cells.</p><p><strong>Method: </strong>Forty-eight healthy guinea pigs were randomly divided into four groups: group A: the control group (0.9% sodium chloride); group B: sodium salicylate [450 mg/(kg x d)] group; group C: sodium salicylate [450 mg/(kg x d)]+chlorpromazine [5 mg/(kg x d)] group; group D: sodium salicylate [450 mg/(kg x d)] +nimodipine [3 mg/(kg x d)] group. The protein expression level of NF-kappaB was examined by immunohistochemical method.</p><p><strong>Result: </strong>The protein expression of NF-kappaB in spiral ganglion cells of group B was significantly higher than that of other groups.</p><p><strong>Conclusion: </strong>Sodium salicylate can promote the protein expression of NF-kappaB in cochlear spiral ganglion cells. Nimodipine and chloropazine can weaken the protein expression of NF-kappaB, which is caused by sodium salicylate in cochlear spiral ganglion cells.</p>","PeriodicalId":79680,"journal":{"name":"Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology","volume":"20 19","pages":"891-3"},"PeriodicalIF":0.0000,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The effect of nuclear factor-kappaB protein expression in spiral ganglion cells of cochlea by overdosage sodium salicylate injection in guinea pigs].\",\"authors\":\"Hong Lü, Lilian Wu, Ying Zeng\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To study the effect of sodium salicylate on the nuclear factor-kappaB (NF-kappaB) protein expression in spiral ganglion cells.</p><p><strong>Method: </strong>Forty-eight healthy guinea pigs were randomly divided into four groups: group A: the control group (0.9% sodium chloride); group B: sodium salicylate [450 mg/(kg x d)] group; group C: sodium salicylate [450 mg/(kg x d)]+chlorpromazine [5 mg/(kg x d)] group; group D: sodium salicylate [450 mg/(kg x d)] +nimodipine [3 mg/(kg x d)] group. The protein expression level of NF-kappaB was examined by immunohistochemical method.</p><p><strong>Result: </strong>The protein expression of NF-kappaB in spiral ganglion cells of group B was significantly higher than that of other groups.</p><p><strong>Conclusion: </strong>Sodium salicylate can promote the protein expression of NF-kappaB in cochlear spiral ganglion cells. Nimodipine and chloropazine can weaken the protein expression of NF-kappaB, which is caused by sodium salicylate in cochlear spiral ganglion cells.</p>\",\"PeriodicalId\":79680,\"journal\":{\"name\":\"Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology\",\"volume\":\"20 19\",\"pages\":\"891-3\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[The effect of nuclear factor-kappaB protein expression in spiral ganglion cells of cochlea by overdosage sodium salicylate injection in guinea pigs].
Objective: To study the effect of sodium salicylate on the nuclear factor-kappaB (NF-kappaB) protein expression in spiral ganglion cells.
Method: Forty-eight healthy guinea pigs were randomly divided into four groups: group A: the control group (0.9% sodium chloride); group B: sodium salicylate [450 mg/(kg x d)] group; group C: sodium salicylate [450 mg/(kg x d)]+chlorpromazine [5 mg/(kg x d)] group; group D: sodium salicylate [450 mg/(kg x d)] +nimodipine [3 mg/(kg x d)] group. The protein expression level of NF-kappaB was examined by immunohistochemical method.
Result: The protein expression of NF-kappaB in spiral ganglion cells of group B was significantly higher than that of other groups.
Conclusion: Sodium salicylate can promote the protein expression of NF-kappaB in cochlear spiral ganglion cells. Nimodipine and chloropazine can weaken the protein expression of NF-kappaB, which is caused by sodium salicylate in cochlear spiral ganglion cells.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
