脉压升高对肾功能的影响。

Albert Mimran
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引用次数: 11

摘要

外周脉压(PP)是五十年后与衰老相关的动脉硬化的标志。此外,PP已成为心血管发病率和死亡率的一个强有力的预测因子。用可靠的方法估计肾血流动力学(有效肾血浆流量)和功能(肾小球滤过率;因此,GFR是在大量从未治疗过的原发性高血压患者中进行的。在212例孤立性收缩期高血压患者中,GFR与PP呈负相关,但在调整年龄后相关性不存在。事实上,仅在60岁及以上的患者中观察到PP对GFR的有害影响,与年龄和平均动脉压无关。相比之下,在40岁及以上、60岁以下和40岁以下的患者中,未发现PP对GFR的明显影响。因此,我们提出PP可能对GFR的年龄相关性下降有不利影响。需要对可能影响外周和中枢PP的降压药对GFR进行性下降的影响进行前瞻性研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Consequences of elevated pulse pressure on renal function.

Peripheral pulse pressure (PP) is a marker of aging-associated arterial stiffening after the fifth decade. In addition, PP has emerged as a strong predictor of cardiovascular morbidity and mortality. A study of the relationship between renal function and aging of the arterial system using reliable methods of estimating renal haemodynamics (effective renal plasma flow) and function (glomerular filtration rate; GFR) was thus undertaken in a large number of never-treated individuals with essential hypertension. In 212 patients with isolated systolic hypertension, there was an inverse correlation between GFR and PP, but the correlation did not persist after adjustment for age. In fact, the deleterious effect of PP on GFR was observed, independent of age and mean arterial pressure, only in patients aged 60 years and over. In contrast, no clear influence of PP on GFR was detected in patients aged 40 years and over but less than 60 years and in those younger than 40 years. It is thus proposed that PP may have a detrimental influence on the age-related decline in GFR. Prospective studies on the influence of antihypertensive agents with possible effects on peripheral and central PP on the progressive decline of GFR are required.

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