K Taniguchi, Y Usui, T Matsuda, S Suzuki, K Fujiki, F Yakusiji, J Tomiyama, K Kinoshita, H Ilzuka, Y Kuga
{"title":"甲氨蝶呤致类风湿关节炎患者急性肺损伤1例。","authors":"K Taniguchi, Y Usui, T Matsuda, S Suzuki, K Fujiki, F Yakusiji, J Tomiyama, K Kinoshita, H Ilzuka, Y Kuga","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Methotrexate (MTX)-induced acute lung injury developed in a female patient with rheumatoid arthritis. She was successfully treated with high-dose glucocorticoid therapy. During her hospital stay, the serum concentration of surfactant protein (SP)-D, which was markedly elevated on admission, was finally normalized and the disease resolved. However, the serum concentration of Klebs von den Lungen (KL)-6 remained high. Although the mechanisms of lung injury by MTX have not been well defined, serial measurements of serum SPD might be useful for the clinical evaluation of drug-induced acute lung injury.</p>","PeriodicalId":13940,"journal":{"name":"International journal of clinical pharmacology research","volume":"25 3","pages":"101-5"},"PeriodicalIF":0.0000,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Methotrexate-induced acute lung injury in a patient with rheumatoid arthritis.\",\"authors\":\"K Taniguchi, Y Usui, T Matsuda, S Suzuki, K Fujiki, F Yakusiji, J Tomiyama, K Kinoshita, H Ilzuka, Y Kuga\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Methotrexate (MTX)-induced acute lung injury developed in a female patient with rheumatoid arthritis. She was successfully treated with high-dose glucocorticoid therapy. During her hospital stay, the serum concentration of surfactant protein (SP)-D, which was markedly elevated on admission, was finally normalized and the disease resolved. However, the serum concentration of Klebs von den Lungen (KL)-6 remained high. Although the mechanisms of lung injury by MTX have not been well defined, serial measurements of serum SPD might be useful for the clinical evaluation of drug-induced acute lung injury.</p>\",\"PeriodicalId\":13940,\"journal\":{\"name\":\"International journal of clinical pharmacology research\",\"volume\":\"25 3\",\"pages\":\"101-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of clinical pharmacology research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of clinical pharmacology research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
甲氨蝶呤(MTX)引起的急性肺损伤发展为女性患者风湿性关节炎。她成功地接受了大剂量糖皮质激素治疗。住院期间，入院时明显升高的血清表面活性蛋白(SP)-D浓度终于恢复正常，病情得到缓解。然而，血清中Klebs von den Lungen (KL)-6的浓度仍然很高。虽然MTX对肺损伤的机制尚未明确，但血清SPD的连续测量可能有助于药物性急性肺损伤的临床评估。
Methotrexate-induced acute lung injury in a patient with rheumatoid arthritis.
Methotrexate (MTX)-induced acute lung injury developed in a female patient with rheumatoid arthritis. She was successfully treated with high-dose glucocorticoid therapy. During her hospital stay, the serum concentration of surfactant protein (SP)-D, which was markedly elevated on admission, was finally normalized and the disease resolved. However, the serum concentration of Klebs von den Lungen (KL)-6 remained high. Although the mechanisms of lung injury by MTX have not been well defined, serial measurements of serum SPD might be useful for the clinical evaluation of drug-induced acute lung injury.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
