COX-2蛋白在结直肠癌中的表达及临床意义

Hong-bing Yao, Ai-guo Wu, You-jiang Chen, Bin-hua Tang
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摘要

目的:探讨结直肠癌中COX-2表达与临床病理因素的关系,探讨COX-2检测的预后价值。方法:采用组织芯片和免疫组化SABC法检测126例晚期结直肠癌患者COX-2表达,回顾性分析COX-2表达与患者临床病理特征及预后的关系。结果:根据COX-2表达程度及分级将患者分为COX-2低表达组和高表达组。COX-2高表达32例(25.4%),低表达94例(74.6%)。COX-2的表达与患者的年龄、性别、肿瘤大小、肿瘤部位、组织学类型、淋巴结转移及Dukes分级无显著相关性,但COX-2的高表达与肿瘤复发密切相关,尤其是与血源性转移密切相关(结论:COX-2的表达与结直肠癌复发密切相关,尤其是与血源性转移密切相关)。COX-2是评估患者预后的独立因素,组织微阵列可快速、方便、经济、准确地检测COX-2,可大规模应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Expression of COX-2 protein in colorectal carcinoma and the clinical implication].

Objective: To investigate the relationship between COX-2 expression and the clinicopathological factors in colorectal carcinoma and assess the prognostic value of COX-2 detection.

Methods: Tissue microarray and immunohistochemistry by SABC method was employed for detecting COX-2 expression in 126 patients with advanced colorectal cancer, and the relationship of COX-2 expression with the clinicopathological features and prognosis of the patients was retrospectively analyzed.

Results: The patients were divided into two groups of low and high COX-2 groups according to the grade and extent of COX-2 expression. High COX-2 expression was detected in 32 (25.4%) cases, and low expression in 94 (74.6%) cases. No significant correlation was noted between COX-2 expression and the patients' age, sex, tumor size, tumor location, histological type, lymphatic-node metastasis and Dukes' classification, but high COX-2 expression was strongly correlated with tumor recurrence and especially with blood-borne metastasis (P<0.05). The survival rate without tumor recurrence for high- and low-COX-2 groups was assessed by the Kaplan-Meier method and compared by log-rank test, which revealed significant difference between the two groups (P=0.0067). Multivariate analysis for all patients suggested that among the 8 prognostic factors (age, sex, tumor size, tumor location, histological type, lymphatic-node metastasis, Dukes' stage, and COX-2 expression), Dukes' stage and COX-2 expression was the independent significant factor related to disease-free survival.

Conclusion: The expression of COX-2 is strongly correlated with recurrence of colorectal cancer, especially with blood-borne metastasis. COX-2 is an independent factor for prognostic evaluation of the patients, and tissue microarray allows rapid, convenient, economic and accurate COX-2 detection for large-scale application.

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