强直性脊柱炎遗传易感性研究进展

Rui-Wen Chen, Yong Wang, Shu-Han Sun, Shi-Wei Duan
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引用次数: 0

摘要

强直性脊柱炎(AS)是一种高度遗传性、常见的炎症性风湿病。自20世纪70年代以来,越来越多的证据表明HLA-B27是参与as易感性的主要基因。然而,全基因组扫描和相关研究表明,除了HLA外,HLA外的区域也与AS易感性有关。此外,有令人信服的证据表明,HLA内或HLA外的非b27基因与疾病病因有关。本文主要综述了与AS相关的不同基因,以及这一令人兴奋的领域的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Progress on genetic susceptibility to ankylosing spondylitis].

Ankylosing spondylitis (AS) is a highly heritable, common inflammatory rheumatic disease. Since 1970s, evidence has increasingly pointed to HLA-B27 as the major gene involved in susceptibility to AS. However, genome-wide scan and association studies have shown, in addition to HLA, regions outside the HLA are involved in susceptibility to AS. Furthermore, there is compelling evidence that non-B27 genes, either within or outside the HLA, are involved in disease aetiology. This review mainly summarized different genes associated with AS, and the current progress in this exciting area.

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