Is breast reduction in puberty indicated? Retrospective observations of patients with a local hypersensitivity of estrogen and progesterone receptors.

The authors described two women in whom at the age of 14 and 15 diagnosed was gigantomasty and a hypersensitivity of the estrogen receptor. In both the patients at that time a significant increase of the estrogen and progesterone receptors in the breast glandular tissue was ascertained. The immunohistochemical investigation shows a significant higher sensitivity of the progesterone and estrogen receptors. In both the girls observed was gigantomasty with hyperlordosis, deformities of the chest and back, skin changes, orthopnoe. In both the patients a total mastectomy was performed. Both the girls had after surgery a normal menstruation, were married with normal sexual activity. One of the patients had a normal delivery two years ago.