口服微量类黄酮治疗慢性静脉功能不全患者的临床和血流动力学结果。

A C Ting, S W Cheng, L L Wu, G C Cheung
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引用次数: 12

摘要

本研究的目的是前瞻性研究达氟治疗轻中度慢性静脉功能不全(CVI)(临床1-4级)患者的临床疗效,并通过空气体积描图(APG)评估静脉血流动力学的变化。对28例患者56条肢体进行了研究。所有患者均有原发性静脉功能不全,无静脉梗阻,其中64%的肢体有深、浅静脉功能不全。达芙蓉治疗6个月后,肿胀和沉重的症状评分显著下降。痉挛的症状评分也有改善,但没有达到统计学意义。治疗前疼痛评分为21.8 +/- 19.3%,治疗6个月后疼痛评分为10.4 +/- 20.2% (p < 0.01)。这也与平均小腿围从37.0 +/- 4.3 cm减少到36.4 +/- 4.3 cm相关(p < 0.001)。Daflon治疗前后6个月静脉充盈指数(VFI)、射血分数(EF)和残余体积分数(RVF)无显著变化(VFI: 3.7 +/- 3.5 vs 3.4 +/- 2.5 mL/s, EF: 54.5 +/- 15.9% vs 57.7 +/- 19.7%, RVF: 41.4 +/- 19.2% vs 39.4 +/- 24.2%)。APG测量的临床改善无相关静脉血流动力学改变,表明大氟主要通过改变APG未检测到的微循环环境起作用,这种微循环改变与临床改善有关。在这方面,对于没有静脉曲张临床证据但有静脉功能不全症状的功能性静脉功能不全患者,Daflon将特别有用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical and hemodynamic outcomes in patients with chronic venous insufficiency after oral micronized flavonoid therapy.

The aim of this study was to prospectively investigate the clinical efficacy of Daflon therapy in patients with mild to moderate chronic venous insufficiency (CVI) (clinical class 1-4) and to assess the changes in venous hemodynamics by using air plethysmography (APG). Fifty-six limbs in 28 patients were studied. They all had primary venous insufficiency with no venous obstruction, and mixed deep and superficial venous incompetence was found in 64% of the limbs. There was a significant decrease in symptom score for swelling and heaviness after 6 months of Daflon therapy. The symptom score for cramps also showed improvement though it did not reach statistical significance. Pain was significantly reduced with a mean pain score of 21.8 +/- 19.3% before comparing to 10.4 +/- 20.2% after 6 months of Daflon therapy (p < 0.01). This was also associated with a decrease in mean calf circumference from 37.0 +/- 4.3 to 36.4 +/- 4.3 cm (p < 0.001). There was no significant change in the venous filling index (VFI), ejection fraction (EF), and residual volume fraction (RVF) before and after 6 months of Daflon therapy (VFI: 3.7 +/- 3.5 vs 3.4 +/- 2.5 mL/s, EF: 54.5 +/- 15.9% vs 57.7 +/- 19.7%, RVF: 41.4 +/- 19.2% vs 39.4 +/- 24.2%). The clinical improvement without associated changes in venous hemodynamics as measured by APG suggests that Daflon mainly works by modifying the microcirculatory environment not detected by APG and this microcirculatory change is associated with clinical improvement. In this regard, Daflon would be especially useful for symptomatic relief in patients with functional venous insufficiency who do not have clinical evidence of varicose veins but suffer from symptoms of venous insufficiency.

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