对ASD行为表型一致性的需求:丙戊酸模型的分析。

Autism Research and Treatment Pub Date : 2021-03-19 eCollection Date: 2021-01-01 DOI:10.1155/2021/8863256
Olivia Larner, Jane Roberts, Jeffery Twiss, Linnea Freeman
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引用次数: 6

摘要

自闭症谱系障碍(ASD)是一种非常普遍的损害性神经发育障碍,影响了1.54人。在过去的几十年里,由于意识的提高和诊断方法的改进,美国ASD的发病率有可能增加。虽然ASD的患病率正在上升,但其病因仍然相对未知。为了更好地了解ASD的神经学基础,已经开发了ASD的啮齿动物模型进行研究。目前,还没有一套标准化的行为测试来量化啮齿动物的类自闭症行为。本综述的目的是概述用于分析啮齿动物asd样行为的方法,重点是丙戊酸(VPA)模型,并说明不同方法之间的不一致性。尽管子宫内VPA啮齿动物ASD模型被广泛使用并被广泛表征,但不同研究人员的行为差异很大。展望未来,行为方法分析的一致性将有利于评估所有ASD模型的干预措施,并有助于揭示导致ASD体征和症状的独特品质和潜在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Need for Consistency in Behavioral Phenotyping for ASD: Analysis of the Valproic Acid Model.

Autism spectrum disorder (ASD) is a highly prevalent and impairing neurodevelopmental disorder that affects 1 : 54 persons. Over the last several decades, the reported incidence of ASD in the US has increased potentially due to increased awareness and improved diagnostic measurement. Although ASD prevalence is increasing, the etiology of ASD remains relatively unknown. To better understand the neurological basis of ASD, rodent models of ASD have been developed for research. Currently, there is not a standardized set of behavioral tests to quantify ASD-like behavior in rodents. The goal of this review is to present an overview of the methodologies used to analyze ASD-like behaviors in rodents, focusing on the valproic acid (VPA) model, and illustrate inconsistencies between different approaches. Despite that the in utero VPA rodent model for ASD is widely used and extensively characterized, behaviors vary substantially between different researchers. Moving forward, consistency in behavioral method analytics would benefit progress in evaluating interventions for all models of ASD and help to uncover unique qualities underlying mechanisms causing ASD signs and symptoms.

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