2 型糖尿病患者心血管自主神经病变与尿白蛋白排泄率和心脏功能的相关性。

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Minerva endocrinology Pub Date : 2024-03-01 Epub Date: 2021-04-01 DOI:10.23736/S2724-6507.21.03358-7
Yunjiang Chen, Yanchun Gong, Kaiyu Cai
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引用次数: 0

摘要

背景:心血管自主神经病变(CAN)与糖尿病肾病和心脏病之间的关系仍然扑朔迷离。本研究旨在探讨 2 型糖尿病(T2DM)患者的心血管自主神经病变与尿白蛋白排泄率(UAER)和心脏功能的相关性:通过心血管反射测试(CARTs)将225名T2DM患者分为CAN组和非CAN组。根据尿白蛋白/肌酐比值(UACR)或左室舒张功能障碍和正常组的左室峰值E/A速度比值(E/A),将他们分为大白蛋白尿组、微白蛋白尿组和正常白蛋白尿组。分析了CAN与白蛋白尿和左心室舒张功能障碍的相关性,以及UACR和E/A的预测价值:结果:与非CAN组相比,CAN组年龄较大,T2DM病程较长,血清尿酸(SUA)水平、UACR、仰卧位和站立位收缩压和舒张压差异较大,其他CARTs参数和E/A较低:在 T2DM 患者中,CAN 与 UAER 和心脏功能的下降呈正相关。UACR 和 E/A 具有很高的预测价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlations of cardiovascular autonomic neuropathy with urinary albumin excretion rate and cardiac function in patients with type 2 diabetes mellitus.

Background: The associations of cardiovascular autonomic neuropathy (CAN) with diabetic nephropathy and heart disease remain elusive. The aim of this study was to explore the correlations of CAN with urinary albumin excretion rate (UAER) and cardiac function in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 225 T2DM patients were assigned into CAN and non-CAN groups using cardiovascular reflex tests (CARTs). They were divided into macroalbuminuria, microalbuminuria and normoalbuminuria groups according to urinary albumin/creatinine ratio (UACR), or left ventricular diastolic dysfunction and normal groups based on left ventricular peak E/A velocity ratio (E/A). The correlations of CAN with albuminuria and left ventricular diastolic dysfunction, and the predictive values of UACR and E/A were analyzed.

Results: Compared with non-CAN group, CAN group had older age, longer T2DM duration, higher serum urine acid (SUA) level, UACR, systolic and diastolic pressure differences between supine and standing positions, and lower other CARTs parameters and E/A (P<0.001). Macroalbuminuria group had largest positional systolic and diastolic pressure differences, and lowest other CARTs parameters (P<0.001). Compared with normal group, left ventricular diastolic dysfunction group had larger positional systolic and diastolic pressure differences, and lower other CARTs parameters (P<0.001). CAN in T2DM patients was positively correlated with albuminuria and left ventricular diastolic dysfunction (P<0.001). Age, SUA, UACR and E/A were independent predictive factors (P=0.031, P=0.005, P<0.001, P<0.001). UACR and E/A had high predictive values.

Conclusions: In T2DM patients, CAN is positively correlated with declined UAER and cardiac function. UACR and E/A have high predictive values.

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CiteScore
4.60
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