UDS 3.0神经心理电池在哥伦比亚阿尔茨海默病队列中的诊断准确性

IF 1.7 4区 心理学
Applied Neuropsychology-Adult Pub Date : 2022-11-01 Epub Date: 2021-03-24 DOI:10.1080/23279095.2021.1897007
Maria F Porto, Juan Camilo Benitez-Agudelo, Daniel Camilo Aguirre-Acevedo, Ernesto Barceló-Martinez, Ricardo F Allegri
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引用次数: 4

摘要

背景:阿尔茨海默病(AD)是一种神经退行性疾病,导致认知功能逐渐丧失并限制日常活动表现。阿尔茨海默病的早期诊断对于及时开始治疗至关重要。本研究旨在在哥伦比亚队列中验证统一数据集神经心理学电池版本3.0 (UDS 3.0)。方法:本研究为横断面型,连续,偶然,共143人,分为两组:48例AD确诊病例和95例健康对照,年龄在50 ~ 80岁以上,1 ~ 19岁以上。结果:在大多数电池测试中,结果表明对照组和AD组之间存在差异。蒙特利尔认知评估(MoCA)、多语言命名测试(MINT)、手工故事、Benson图测试、p字和f字音位流畅性测试与其各自的参考测试之间存在显著相关。根据每个子测试的约登指数找到分界点。结果表明,所有子试验均在ROC曲线基准线以上。结论:在哥伦比亚使用UDS 3.0有助于改善临床诊断途径,因为它具有较高的准确性和与一般损害检测的高相关性;具有良好的敏感性和特异性,可作为诊断AD的有效工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic accuracy of the UDS 3.0 neuropsychological battery in a cohort with Alzheimer's disease in Colombia.

Background: Alzheimer's disease (AD) is a neurodegenerative disease that causes a gradual loss of cognitive functions and limits daily activities performance. Early diagnosis of AD is essential to start timely treatment. This study aimed to validate the Uniform Data Set neuropsychological battery version 3.0 (UDS 3.0) in a Colombian cohort.

Methods: This study is a cross-sectional type, consecutive, incidental, with 143 persons, divided into two groups: 48 diagnosed AD cases and 95 healthy controls, between the ages of 50 and 80+, and between 1 and 19+ years of education.

Results: The results indicate differences between the control group and the AD group in most battery tests. A significant correlation was found between the Montreal Cognitive Assessment (MoCA), Multilingual Naming Test (MINT), Craft Story, Benson Figure Test, P-word and F-word Phonemic Fluency Test, and their respective reference tests. Cutoff points were found based on the Youden index for each sub-test. The results indicate that all sub-tests are above the reference line of the ROC curve.

Conclusion: The use of the UDS 3.0 in Colombia would help improving clinical diagnostic routes because of its high accuracy and high correlation with tests that measure general impairment; it has good sensitivity and specificity, and it can be a useful tool for AD.

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来源期刊
Applied Neuropsychology-Adult
Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY
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