错误地服用重复负荷剂量的Degarelix导致急性精神病。

JRSM Open Pub Date : 2021-02-19 eCollection Date: 2021-02-01 DOI:10.1177/2054270420983105

Musaab Hamdoon, Maria Satchi, Fay Fawke, Sanjeev Madaan

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引用次数: 1

摘要

晚期和转移性前列腺癌通常用激素阻断治疗。促黄体激素释放激素拮抗剂可快速抑制睾丸激素，用于晚期或转移性前列腺癌的治疗。Degarelix是一种促黄体生成素释放激素拮抗剂，作为负荷剂量给予，随后每月维持剂量。我们报告了一个病例，患者无意中被给予第二剂量的Degarelix，导致急性精神病，表现为恐慌发作、妄想、自杀念头、失眠和一些视觉幻觉，这些都没有被报道为Degarelix的副作用。

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Mistaken administration of a repeat loading dose of Degarelix leading to acute psychosis.

Advanced and metastatic prostate cancer is often managed with hormonal blockage. Luteinising hormone-releasing hormone antagonists achieve rapid testosterone suppression and are used for the treatment of advanced or metastatic prostate cancer. Degarelix is a luteinising hormone-releasing hormone antagonist and is given as a loading dose, followed by a monthly maintenance dose. We report a case where a patient was inadvertently given a second loading dose of Degarelix that resulted in acute psychosis in the form of panic attacks, delusions, suicidal thoughts, insomnia and some visual hallucinations, which are not reported as side-effects of Degarelix.

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来源期刊

JRSM Open

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： JRSM Open is a peer reviewed online-only journal that follows the open-access publishing model. It is a companion journal to the Journal of the Royal Society of Medicine. The journal publishes research papers, research letters, clinical and methodological reviews, and case reports. Our aim is to inform practice and policy making in clinical medicine. The journal has an international and multispecialty readership that includes primary care and public health professionals.