通过吸入给 Sprague Dawley (Hsd:Sprague Dawley SD) 大鼠和 B6C3F1/N 小鼠施用邻苯二甲醛(化学文摘社编号 643-79-8)的毒性研究。

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引用次数: 0

摘要

邻苯二甲醛是一种高级化学消毒剂,常用于牙科和医疗器械的消毒,是戊二醛的替代品,而戊二醛是一种已知的皮肤和呼吸道致敏物质。邻苯二甲醛由美国国家职业安全与健康研究所提名进行毒理学特征描述,其依据是:邻苯二甲醛被提议作为戊二醛的更安全替代品用于化学消毒;邻苯二甲醛的使用量不断增加;缺乏足够的公开毒理学数据;以及许多人类病例报告记录了职业性接触邻苯二甲醛后皮肤和呼吸道致敏的发生率。这些研究选择吸入作为接触途径,因为吸入是人类职业接触的主要途径。雌雄 Sprague Dawley(Hsd:Sprague Dawley SD)大鼠和 B6C3F1/N 小鼠通过全身吸入的方式接触邻苯二甲醛(纯度为 99.7%),为期 3 个月。(摘要有删节)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toxicity studies of o-phthalaldehyde (CASRN 643-79-8) administered by inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.

o-Phthalaldehyde is a high-level chemical disinfectant that is commonly used for disinfection of dental and medical instruments as an alternative to glutaraldehyde, which is a known skin and respiratory sensitizer. o-Phthalaldehyde was nominated by the National Institute for Occupational Safety and Health for toxicologic characterization based on its proposed use as a safer alternative to glutaraldehyde for chemical disinfection, its increasing use, the lack of adequate and publicly available toxicologic data, and because many human case reports document incidences of skin and respiratory sensitization following occupational exposure. Inhalation was chosen as the route of exposure for these studies because inhalation is a major route of human occupational exposure. Male and female Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice were exposed to o-phthalaldehyde (99.7% pure) by whole-body inhalation for 3 months. (Abstract Abridged).

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