傅里叶红外光谱法定量分析布吉拉胺及其制剂

Farmaco (Societa chimica italiana : 1989) Pub Date : 2005-08-01 DOI:10.1016/j.farmac.2005.05.008

Andrei A. Bunaciu , Hassan Y. Aboul-Enein , Şerban Fleschin

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引用次数: 7

摘要

建立了一种快速、直接测定布吉拉胺的傅里叶变换红外光谱法。比较了常规kbr光谱和DRIFTS光谱测定其片剂中活性物质的最佳方法。两种化学计量学方法，偏最小二乘(PLS)和主成分回归(PCR+)方法用于数据处理。两种化学计量方法得到了相似的结果。

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Quantitative analysis of bucillamine and its pharmaceutical formulation using FT-IR spectroscopy

A Fourier transform infrared (FT-IR) spectrometric method was developed for the rapid, direct measurement of bucillamine. Conventional KBr-spectra and DRIFTS spectra were compared for best determination of active substance in its tablet formulation. Two chemometric approaches, partial least squares (PLS) and principal component regression (PCR+) methods were used in data processing. Similar results were obtained with both chemometric methods.

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Farmaco (Societa chimica italiana : 1989)

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