[胃饥饿素在调节能量稳态中的作用]。

Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych Pub Date : 2005-01-01

Ewa Otto Buczkowska

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引用次数: 0

摘要

生长素(Ghrelin)是一种由28个氨基酸组成的新型肽，是生长激素促分泌素受体的内源性配体。胃是胃饥饿素循环的主要来源，但它也由肠、肾、下丘脑、垂体、胎盘和胰腺产生。Ghrelin被认为是生长激素分泌的重要调节因子，在能量稳态、糖脂代谢、生殖、心血管功能和免疫等方面具有重要作用。Ghrelin已被证明在控制食物摄入方面具有生理作用，作为一种促氧激素，可能是通过刺激NPY的产生而与瘦素的作用相反。

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[The role of ghrelin in the regulation of energy homeostasis].

Ghrelin, a novel 28 amino acid peptide, is the endogenous ligand for the growth hormone secretagogue receptor. The stomach is the primary source of circulating ghrelin, but it is also produced by the intestines, kidneys, hypothalamus, pituitary, placenta and pancreas. Ghrelin has been recognized as an important regulator of GH secretion and have important roles in energy homeostasis, glucose and lipid metabolism, reproduction, cardiovascular function, and immunity. Ghrelin has been shown to have a physiological role in the control of food intake, acting as an orexigenic hormone, probably by stimulating NPY production in contrast to the actions of leptin.

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Endokrynologia, diabetologia i choroby przemiany materii wieku rozwojowego : organ Polskiego Towarzystwa Endokrynologow Dzieciecych

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