甲状旁腺激素,整形手术用的药物?

Ralf Skripitz, Per Aspenberg
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引用次数: 54

摘要

而连续暴露于甲状旁腺激素导致骨吸收,间歇剂量的管理导致骨形成通过增加成骨细胞的数量和活性。甲状旁腺激素的合成代谢作用也在临床试验中得到证实,甲状旁腺激素增加骨质疏松症患者的骨量,降低骨折率。在骨科植入物骨折愈合和固定的动物模型中,甲状旁腺激素以剂量依赖的方式增加骨密度,导致更快的修复和更好的固定。这种作用对新生骨的影响似乎比对原有骨的影响更大。基于这些临床前研究,我们建议间歇性甲状旁腺激素治疗也可能有利于患者骨折愈合和植入物固定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Parathyroid hormone--a drug for orthopedic surgery?

Whereas continuous exposure to PTH results in bone resorption, administration at intermittent doses results in bone formation by increasing osteoblast number and activity. The anabolic action of PTH has also been demonstrated in clinical trials, in which PTH increased the bone mass and reduced fracture rate in patients with osteoporosis. In animal models of fracture healing and fixation of orthopedic implants, PTH increases the bone density in a dose-dependent manner, leading to faster repair and better fixation. The effect appears to be stronger on the new forming bone than on pre-existing bone. Based on these preclinical studies, we suggest that intermittent PTH treatment may also benefit fracture healing and implant fixation in patients.

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