绝经后高血压发病机制的基础研究。

Jane F Reckelhoff
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引用次数: 0

摘要

绝经后,女性心血管疾病(CVD)的发病率通常会增加。心血管疾病的主要危险因素包括高血压,绝经后,女性血压升高。造成这一增长的机制尚未确定。雌激素/雄激素比例的变化,肾素-血管紧张素系统的可能激活,内皮素和氧化应激的增加,是绝经后妇女的特征。肥胖、2型糖尿病和交感神经系统的激活也可能起重要作用。然而,由于缺乏合适的动物模型,阐明绝经后高血压机制的进展受到阻碍。我们最近描述了衰老的雌性自发性高血压大鼠(SHR)作为绝经后高血压的模型,因为这种菌株表现出许多绝经后妇女的体液特征。这篇综述讨论了一些可能在绝经后高血压中发挥作用的机制,以及衰老女性SHR作为模型的特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Basic research into the mechanisms responsible for postmenopausal hypertension.

Women typically experience increased cardiovascular disease (CVD) following menopause. Major risk factors for CVD include hypertension and, after menopause, blood pressure increases in women. The mechanism(s) responsible for this increase are not determined. Changes in oestrogen/androgen ratios, possible activation of the renin-angiotensin system, and increases in endothelin and oxidative stress, are hallmarks in postmenopausal women. Obesity, type 2 diabetes and activation of the sympathetic nervous system may also play important roles. However, progress in clarifying the mechanisms responsible for postmenopausal hypertension has been hampered by lack of a suitable animal model. We have recently characterised the ageing female spontaneously hypertensive rat (SHR) as a model of postmenopausal hypertension, since this strain exhibits many of the humoral characteristics of postmenopausal women. This review discusses some of the mechanisms that could play a role in postmenopausal hypertension, as well as the characteristics of the ageing female SHR as a model.

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