Iryna G Vasilyeva, Mikhail I Shamaev, Alexandr Ya Glavatskiy, Natalya G Chopick, Natalya P Olexenko, Olga I Tsyubko, Elena S Galanta, Tatyana A Malisheva
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Detection of polyomavirus DNA in human brain tumors.
Aim: To investigate surgically resected human brain tumors for the presence of polyomavirus DNA.
Materials and methods: 65 samples of surgically resected human brain tumors (57 tumors were of neuroectodermal genesis, 4--mesenchimal, 4--metastatic tumors) were examined for the presence of viral DNA by PCR analysis.
Results: DNA of polyomaviruses was found in oligodendroligomas (66.7% of cases), oligodendroastrocytomas (66.7% of cases) and glioblastomas (40% of cases). In metastatic tumors viral infection had not been detected. No correlation between the grade of brain tumors and infection with polyomavirus DNA has been revealed.
Conclusion: Our data point to importance of investigation of the brain tumors and cerebrospinal fluid for determination of viral infection.
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