多糖蛋白和多糖肽偶联物的化学合成研究进展

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2021-11-15 DOI:10.1016/j.carbpol.2021.118662

Yang Zhou , Stella P. Petrova , Kevin J. Edgar

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引用次数: 27

摘要

多糖是丰富的天然聚合物，在自然界中有时与多肽和蛋白质共价修饰。与天然多肽和蛋白质相比，天然或非天然的多糖-蛋白质或多糖-肽缀合物可能具有更高的溶解度，改善的乳液特性，延长的循环时间，降低的免疫原性，以及针对特定组织的更高选择性。本文综述了多糖蛋白缀合物的合成方法的最新进展，并重点讨论了它们在药物靶向方面的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemical synthesis of polysaccharide–protein and polysaccharide–peptide conjugates: A review

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Chemical synthesis of polysaccharide–protein and polysaccharide–peptide conjugates: A review

Polysaccharides are abundant natural polymers, which in nature are at times covalently modified with peptides and proteins. Polysaccharide–protein or polysaccharide–peptide conjugates, natural or otherwise, may have increased solubility, improved emulsion properties, prolonged circulation time, reduced immunogenicity, and enhanced selectivity for targeting specific tissues compared to native peptides and proteins. In this paper, we will review recent advances in synthetic methods for producing polysaccharide–protein conjugates and discuss their advantages with a focus on drug targeting.

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.