{"title":"参麦注射液对家兔离体心脏DPPH自由基损伤的保护作用。","authors":"Nian-sheng Li, Xiao-ming Xiong, Li-ying Liu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To examine the protective effects of shenmai injection (SM) on DPPH free radical-induced myocardial injury in isolated hearts in rabbits.</p><p><strong>Methods: </strong>The isolated rabbit hearts were perfused in a Langendorff model. The left ventricular pressure (LVP), the first derivative of LVP (+dp/dtmax), left ventricular end-diastolic pressure (LVEDP) and heart rate(HR) were recorded. Coronary flow (CF) and creatine Kinase (CK) of coronary issue were measured.</p><p><strong>Results: </strong>Perfusion with DPPH (0.25 mumol/L) for 5 min caused a significant impairment of cardiac function, as shown by a decrease in LVP and +dp/dtmax and an increase in LVEDP as well as the increased release of CK. Pretreatment with shenmai injection (1:320) for 10 min significantly improved the cardiac function and decreased the release of CK.</p><p><strong>Conclusion: </strong>Shenmai injection protects against the myocardial injury induced by free radical (DPPH) in isolated rabbit hearts.</p>","PeriodicalId":13115,"journal":{"name":"Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University","volume":"28 3","pages":"247-50"},"PeriodicalIF":0.0000,"publicationDate":"2003-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Protective effects of shenmai injection on DPPH free radical-induced injuries in isolated hearts in rabbits].\",\"authors\":\"Nian-sheng Li, Xiao-ming Xiong, Li-ying Liu\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To examine the protective effects of shenmai injection (SM) on DPPH free radical-induced myocardial injury in isolated hearts in rabbits.</p><p><strong>Methods: </strong>The isolated rabbit hearts were perfused in a Langendorff model. The left ventricular pressure (LVP), the first derivative of LVP (+dp/dtmax), left ventricular end-diastolic pressure (LVEDP) and heart rate(HR) were recorded. Coronary flow (CF) and creatine Kinase (CK) of coronary issue were measured.</p><p><strong>Results: </strong>Perfusion with DPPH (0.25 mumol/L) for 5 min caused a significant impairment of cardiac function, as shown by a decrease in LVP and +dp/dtmax and an increase in LVEDP as well as the increased release of CK. Pretreatment with shenmai injection (1:320) for 10 min significantly improved the cardiac function and decreased the release of CK.</p><p><strong>Conclusion: </strong>Shenmai injection protects against the myocardial injury induced by free radical (DPPH) in isolated rabbit hearts.</p>\",\"PeriodicalId\":13115,\"journal\":{\"name\":\"Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University\",\"volume\":\"28 3\",\"pages\":\"247-50\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Protective effects of shenmai injection on DPPH free radical-induced injuries in isolated hearts in rabbits].
Objective: To examine the protective effects of shenmai injection (SM) on DPPH free radical-induced myocardial injury in isolated hearts in rabbits.
Methods: The isolated rabbit hearts were perfused in a Langendorff model. The left ventricular pressure (LVP), the first derivative of LVP (+dp/dtmax), left ventricular end-diastolic pressure (LVEDP) and heart rate(HR) were recorded. Coronary flow (CF) and creatine Kinase (CK) of coronary issue were measured.
Results: Perfusion with DPPH (0.25 mumol/L) for 5 min caused a significant impairment of cardiac function, as shown by a decrease in LVP and +dp/dtmax and an increase in LVEDP as well as the increased release of CK. Pretreatment with shenmai injection (1:320) for 10 min significantly improved the cardiac function and decreased the release of CK.
Conclusion: Shenmai injection protects against the myocardial injury induced by free radical (DPPH) in isolated rabbit hearts.
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